نتایج جستجو برای: alpha activity

تعداد نتایج: 1294400  

Journal: :Cancer research 2008
Elise Meoli Ioannis Bossis Laure Cazabat Manos Mavrakis Anelia Horvath Sotiris Stergiopoulos Miriam L Shiferaw Glawdys Fumey Karine Perlemoine Michael Muchow Audrey Robinson-White Frank Weinberg Maria Nesterova Yianna Patronas Lionel Groussin Jérôme Bertherat Constantine A Stratakis

Most PRKAR1A tumorigenic mutations lead to nonsense mRNA that is decayed; tumor formation has been associated with an increase in type II protein kinase A (PKA) subunits. The IVS6+1G>T PRKAR1A mutation leads to a protein lacking exon 6 sequences [R1 alpha Delta 184-236 (R1 alpha Delta 6)]. We compared in vitro R1 alpha Delta 6 with wild-type (wt) R1 alpha. We assessed PKA activity and subunit e...

Adrenergic receptors have an important role in neural excitability and synaptic plasticity. Despite a lot of studies on these receptors, their exact role in brain disorders accompanied with hyperexcitability has not been determined. There are also controversies on their role in synaptic plasticity. In this review article, the important studies done in this regard have been reviewed to achieve a...

Journal: :Peptides 2009
Madhuri Tahsina Shireen S K Venugopal Dipankar Ghosh Ravisekhar Gadepalli Benu Dhawan Kasturi Mukhopadhyay

Alpha-melanocyte stimulating hormone (alpha-MSH) is an endogenous anti-inflammatory peptide reported to possess antimicrobial properties, however their role as antibacterial peptides is yet to be established. In the present study, we examined in vitro antibacterial activity of alpha-MSH against S. aureus strain ISP479C and several methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) S....

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