A continuous flow system for the synthesis of enantioenriched diarylmethanols from aldehydes is described. The system uses an amino alcohol-functionalized polystyrene resin as the catalyst, and the arylating agent is conveniently prepared by transmetallation of triarylboroxins with diethylzinc.

Considering many applications of functionalized metal oxide nanoparticles in magnetic resonance imaging, drug delivery, neutron irradiation, electronics, catalysis and optics; herein, a new strategy is developed to functionalize magnetite nanoparticles to improve their performances in the delivery of acyclovir. In this study, magnetite Fe3O4 nanoparticles are synthesized b...

The development of syntheses providing enantiomerically pure alpha-amino acids has intrigued generations of chemists and been the subject of intense research. This report describes a general approach to functionalized alpha-amino acids based on catalytic asymmetric synthesis. Proline catalyzed Mannich-type reactions of N-PMP-protected alpha-imino ethyl glyoxylate with a variety of unmodified ke...

Highly amino-functionalized fluorescent carbon nanoparticles (CNPs) were fabricated by hydrothermal carbonization of chitosan at a mild temperature. They were applied to bioimaging of human lung adenocarcinoma A549 cells, showing low cytotoxicity and excellent biocompatibility.

Synthesis and characterization of novel Tea Tree Oil (TTO) loaded antibacterial polyurethane rigid foams using two distinct methods is reported. In the first method, 3-aminopropyltriethoxysilane (APTS) functionalized mesoporous silica was used as carrier TTO for preparing amino-functionalized (TTO-NH2-MCM-41). second one, encapsulated by via sol-gel then APTS, nanocontainers with amino groups (...

The first tertiary amine-catalyzed multicomponent tandem Strecker-allylic-alkylation (SAA) reaction has been developed, which provides a facile access to functionalized α-amino nitriles, which could be readily converted into α-methylene-γ-butyrolactams.

A Simple and efficient method for synthesis of tetrahydropyrimido[4,5-b]quinoline derivatives via three component reaction of aromatic aldehydes, dimedone and 6-amino uracil derivatives using a catalytic amount of sulfonic acid functionalized nanoporous silica (SBA-15-Pr-SO3H) is described. The advantages of this method are easy and clean work-up, high yield, mild reaction c...

Two darts in the middle! This work reports double addition of propargylzinc reagents to nitriles (acylcyanohydrins and cyanocarbonates). methodology provides a straightforward access dipropargylic α,α-disubstituted hydroxyamides or N-Boc-protected amino alcohols which can be converted into functionalized pyridine derivatives after cobalt-catalyzed [2+2+2] cycloaddition reactions involving nitri...

In this work, we report for the first time a new methodology eco-synthesis of 2-amino-4H-chromenes 1, from salycilaldehydes and cyano compounds, under solvent-free mild conditions, using amino-grafted MOFs as catalysts. The selected − commercial CuBTC MIL-100(Sc) previously synthetized in our laboratories can be easily functionalyzed with amines different nature showing notable differences thei...