XR5944, a deoxyribonucleic acid (DNA) bis-intercalator with potent anticancer activity, can bind the estrogen response element (ERE) sequence to inhibit estrogen receptor-α activities. This novel mechanism of action may be useful for overcoming drug resistance to currently available antiestrogen treatments, all of which target the hormone-receptor complex. Here we report the nuclear magnetic re...

Max-Planck-Institut für Strahlenchemie, Stiftstraße 34—36. D-4330 Mülheim a .d . Ruhr. West Germany Z. Naturforsch. 41b, 505—513 (1986); received O ctober 29, 1985 Radiation Chemistry, Amines, Electron Transfer. Hydrogen Abstraction, Reaction Kinetics Hydroxyl radical reactions with trimethylamine in aqueous solution lead to the formation of the aminoalkyl radical (C H ,)2NCH; (A ) and its conj...

We present the synthesis and selected physicochemical properties of several novel symmetrical and unsymmetrical alpha,omega-nucleobase mono- and bis-amide conjugated systems containing aliphatic, aromatic or saccharidic linkages. The final stage of the synthesis involves condensation of a subunit bearing carboxylic group with an amine subunit. 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpho...

Despite the fact that nucleophilic displacement (SN2) of alkyl halides with nitrogen nucleophiles is one first reactions introduced in organic chemistry teaching, its practical utilization largely limited to unhindered (primary) or activated (?-carbonyl, benzylic) substrates. Here, we demonstrate an alternative amination strategy where iodides are used as radical precursors instead electrophile...