background: the aim of this study was to evaluate the radioprotective capacity of some novel aminoalkylated dithiocarbamic acid potassium salts against γ-irradiation in mice. materials and methods: eight compounds containing 2-aminoethyl-, 3- aminopropyl-, 4-aminobutyl-, 5-aminopentyl-, 6- aminohexyl-, 7-aminoheptyl-, 8-aminooctyl and 9- aminononyl of dithiocarbamate derivatives were prepared. ...

An improved synthesis of a family of amino acids that contain ω-aminoalkyl groups and of a new family containing ω-carboxyalkyl groups linked to the R-amine is described. The synthesis was performed by alkylation of suitably monoprotected alkylenediamines and protected ω-amino acids with triflates of R-hydroxy acid esters. The reaction proceeded with inversion of configuration yielding opticall...

The syntheses of calix[4]arene dimelamines that are functionalized with alkyl, aminoalkyl, ureido, pyridyl, carbohydrate, amino acid and peptide functionalities, and their self-assembly with barbituric acid or cyanuric acid derivatives into well-defined hydrogen-bonded nanostructures are described. The thermodynamic stability of these hydrogen-bonded assemblies was studied by CD spectroscopy in...

Mono- and dipeptide derivatives of C4-beta-aminoalkyl carbapenems were synthesized by the use of amino acid N-carboxy anhydride for the peptide bond formation. They were shown to act as prodrugs in vivo while imparting the much desired chemical stability. The beta-chloroalanyl derivative was suggested to act, in part, as a "dual-purpose" antibacterial.

A series of novel (1-aminoalkyl)(trifluoromethyl)- and -(difluoromethyl)phosphinic acids - analogues of proteinogenic and nonproteinogenic α-amino acids were prepared. The synthetic methodology was based on nucleophilic addition of (trifluoromethyl)phosphinic acid or (difluoromethyl)phosphinic acid or its ethyl ester to substrates with C=N or activated C=C double bonds. Analogues of glycine, ph...

Halogen and aminoalkyl derivatives of methyl 5-methoxy-2-methyl-1-benzofuran-3-carboxylate were prepared using 5-hydroxy-2-methyl-3-benzofuranocarboxylic acid as starting material. (1)H-NMR spectra were obtained for all of the synthesized structures, and for compounds 1 and 2 X-ray crystal structures were obtained too. All derivatives were tested for antimicrobial activity against a selection o...

Translation of the genetic code and protein synthesis from amino acids takes place in the ribosome’s where tRNAs act as key intermediates. Correct translation of genetic information into the specific amino acids is dependent on aminoacyl-tRNA ́s. The synthesis of these is catalyzed by aminoacyl-tRNA synthetase. The aminoacylation reaction, the so-called charging of tRNA is carried out in two ste...

Five-membered nitrogen heterocycles such as g-lactams and pyrroles are found in various natural products and pharmaceuticals. Construction of these skeletons in a simple and efficient manner is one of the most important topics in synthetic organic chemistry. In this context, the development of a novel synthetic approach for g-aminocarbonyl compounds composed of a secondary or primary amine moie...

The primary aminoalkyl(bisphosphanyl)ferrocenes 2-(N,N-dimethylaminomethyl)-1,1'-bis(phosphanyl)ferrocene (3a) and N,N-dimethyl-1-[1',2-bis(phosphanyl)ferrocenyl]ethylamine (3b) are readily available in two steps from the corresponding aminoalkylferrocenes. Deprotonation of 3a gave the first alkali metal aminoalkyl(bisphosphanido)ferrocene (4) as a one-dimensional polymer.