PURPOSE To measure the interfraction setup variation of patient undergoing intensity-modulated radiation therapy (IMRT) of head and neck cancer. The data was used to define adequate treatment CTV-to-PTV margin. MATERIALS AND METHODS During March to September 2006, data was collected from 9 head and neck cancer patients treated with dynamic IMRT using 6 MV X-ray beam from Varian Clinac 23EX. W...

PURPOSE The phase III 22071-26071 trial was designed to evaluate the addition of panitumumab to adjuvant chemotherapy plus intensity modulated radiotherapy (IMRT) in locally advanced resected squamous cell head and neck cancer. We report the results of the dummy run (DR) performed to detect deviations from protocol guidelines. METHODS AND MATERIALS DR datasets consisting of target volumes, or...

although more than 98% of the human genome is transcribed, most of these transcripts are not translated into proteins. rather, they are considered as non-coding rnas. micrornas (mirnas) are very short non-coding rnas approximately 22 nucleotides in length which regulate many key processes of cells such as growth, proliferation, differentiation, cell cycle, apoptosis (programmed cell death) and ...

This study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (TS) inhibitor. The designed scaffold is a combination of nucleobase, amino acid and aziridine structures. The candidates are docked into TS and three DNA double strand structures and evaluated based on their binding interaction energies and ligand efficienci...

introduction: recently, magnetic resonance spectroscopic imaging (mrsi), as a functional imaging method, has been used for clinical target volume definition. in this study, we used this method to define the target volume in prostate radiotherapy. material and method: in this study, we used images of 20 prostate cancer cases. mrsi and mri images were fused with ct images. then, treatment plannin...

this study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (ts) inhibitor. the designed scaffold is a combination of nucleobase, amino acid and aziridine structures. the candidates are docked into ts and three dna double strand structures and evaluated based on their binding interaction energies and ligand efficienci...

the interaction of radiation with cells and tissues has a random nature. therefore, understanding the random nature of cell killing that is determined by poisson distribution statistics is an essential point in education of radiation biology. radbiostat is a newly developed educational matlab-based software designed for computer-assisted learning of the target theory in radiation biology. altho...

conclusions chronic use of opioids may lead to alterations in sexual features and sexual hormones. therefore, opioids have the potential to cause infertility. these changes may result from the effect of the drugs on the hypophysis or hypothalamus, the direct effect of the drugs on the seminiferous tubules, or a combination of both. the findings suggest that public awareness about addiction may ...