نتایج جستجو برای: animal modelsepileptogenesispathogenesis of epilepsytemporal lobe epilepsy
تعداد نتایج: 21189777 فیلتر نتایج به سال:
background and objective: temporal lobe epilepsy (tle) usually leads to memory deficit. in this study, we tried to assess the effect of withania somnifera extract on the impaired learning and memory in the intrahippocampal kainate model of tle in the rat. materials & methods: male rats (n=32) were divided into sham, extract+sham, kainite, and kainite+extract. for induction of epilepsy, uni...
BACKGROUND Proton magnetic resonance spectroscopy (1H-MRS) is a potentially useful tool in the in vivo investigation of brain metabolites in intractable temporal lobe epilepsy (TLE). Focal N-acetylaspartate (NAA) reductions have been correlated with mesial temporal sclerosis (MTS) in surgically resected epileptogenic foci. OBJECTIVE To evaluate the abnormalities in the metabolites NAA, creati...
Keywords: Myotonic dystrophy, Dystrophia Myotonica Protein Kinase (DMPK) gene, Epilepsy, Temporal lobe
Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A
Epilepsy comprises several syndromes, amongst the most common being mesial temporal lobe epilepsy with hippocampal sclerosis. Seizures in mesial temporal lobe epilepsy with hippocampal sclerosis are typically drug-resistant, and mesial temporal lobe epilepsy with hippocampal sclerosis is frequently associated with important co-morbidities, mandating the search for better understanding and treat...
Interictal mood and personality disorders in temporal lobe epilepsy and juvenile myoclonic epilepsy.
BACKGROUND Mood disorders have been described as the commonest psychiatric disorders in patients with temporal lobe epilepsy. Secondary depression in temporal lobe epilepsy could be interpreted either as an adjustment reaction to a chronic disease or as a limbic dysfunction. To clarify this issue, a controlled study of psychiatric disorders was conducted in different forms of epileptic and non-...
Objective: The hypotheses related to the fact of epileptic mechanisms are mainly based on excitation-inhibition imbalance in central nervous system. GAERS (Genetic Absence Epilepsy Rats from Strasbourg) is a well-known animal model absence epilepsy, and frequently used experimental studies. In present study, we aimed examine possible morphological gamma-aminobutyric acid (GABA) density changes ...
epilepsy is a disorder categorized by recurrent seizures and leads to changes in neuronal death and neurogenesis. recently the search for new targets in the therapy of epilepsy has focused on brain inflammation because brain inflammation and the associate blood brain barrier damage appears to be basic part of epilepsy pathophysiology-erythropoietin (epo) regulates biological processes counting ...
BACKGROUND Temporal lobe epilepsy is associated with a significant risk of psychosis but there are only limited studies investigating the underlying neurobiology. AIMS To characterise neuroanatomical changes in temporal lobe epilepsy and comorbid psychosis. METHOD The study population comprised all individuals with temporal lobe epilepsy on the epilepsy database at the National Centre for E...
The dentate gyrus of hippocampus has long been considered as a focal point for studies on mechanisms responsible for the development of temporal lobe epilepsy (TLE). Change in intrinsic properties of dentate gyrus granule cells (GCs) has been considered as an important factor responsible in temporal lobe seizures. In this study, we evaluated the intrinsic properties of GCs, during acute phase o...
The dentate gyrus of hippocampus has long been considered as a focal point for studies on mechanisms responsible for the development of temporal lobe epilepsy (TLE). Change in intrinsic properties of dentate gyrus granule cells (GCs) has been considered as an important factor responsible in temporal lobe seizures. In this study, we evaluated the intrinsic properties of GCs, during acute phase o...
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