OBJECTIVES Localization of small, non-visible and non-palpable subcentimetre nodules can be challenging during video-assisted thoracoscopic surgery (VATS). Intraoperative ultrasonography is an option for localization of such lesions, yet this technology has not been fully adapted to thoracic surgery. The objective of this study was to assess a newly developed thoracoscopic ultrasound for locali...

Background: Acoustic cavitation which occurs at high intensities of ultrasound waves can be fatal for tumor cells; however, it can be used to destroy cancer cells as an efficient therapeutic method. On the other hand, it is known that the existence of nanoparticles in a liquid decreases the acoustic cavitation onset threshold. Materials and Methods: In this work, the combined effects of therape...

introduction: to report our experience with a large series of surgical procedures for removal of cerebellopontine angle (cpa) tumors using different approaches.   materials and methods: this was a retrospective analysis of 50 patients (mean age, 49 years) with cpa tumors (predominantly acoustic neuroma) who underwent surgical removal using appropriate techniques (principally a translabyrinthine...

ABSTRACTIntracranial tumours often require radiotherapeutic approaches that differ from other sites. Their specific requirements merit a specialized discussion. A brief review of radiotherapy techniques to treat intracranial tumours is presented with emphasis on the author’s own experience and work, where appropriate. A clinical introduction is presented first followed by a description of bot...

BACKGROUND Morphine stimulates angiogenesis and cancer progression in mice. We investigated whether morphine influences tumour onset, development, and animal model survival, and whether µ-opioid receptor (MOR), lymphangiogenesis, mast cell activation, and substance P (SP) are associated with the tumour-promoting effects of morphine. METHODS Transgenic mice with a rat C3(1) simian virus 40 lar...

One of the key problems when treating patients with malignant gliomas is that despite being able to remove the major bulk of the tumour, tumour cells may have already spread to distant sites of the brain. The aim of the present study is to develop a GFP positive tumour cell line (named NS1) where these cells could be identified for future treatment studies in fully immunocompetent animals. Five...

O6-alkylguanine DNA-alkyltransferase (ATase) provides protection against the toxic, mutagenic and carcinogenic effects of alkylating agents, principally by removing the promutagenic lesion O6-alkylguanine from DNA. Differences in ATase activity in human tissue may thus determine mutational susceptibility. As GC-->AT transitions, which can be induced by O6-alkylguanine in DNA, are commonly obser...