Tuberculosis (TB) still becomes a significant health problem in Indonesia. The first-line anti-tuberculosis drug (ATD) is the most effective TB drug, but it can have some side effects. One of them allergic skin reactions that affect patient's compliance. Allergic due to ATD are found 4-6% cases and third frequent effect after gastrointestinal liver function disorder. All cause reactions. be mil...

Hepatic hydatid disease is very common in developing nations. Although anaphylactic shock a rare complication during anaesthesia, it can present with severe cardiovascular and hypersensitive reactions surgical removal of cyst, requiring prompt emergency management. We report case 43 year old female posted for elective cyst the right lobe liver under general anaesthesia. An anaesthesist should b...

Anaphylactic shock is a severe allergic reaction involving multiple organs including the bronchial and cardiovascular system. Most anaphylactic mediators, like platelet-activating factor (PAF), histamine, and others, act through G protein-coupled receptors, which are linked to the heterotrimeric G proteins G(q)/G(11), G(12)/G(13), and G(i). The role of downstream signaling pathways activated by...

Although several workers have produced in vitro inhibition of the anaphylactic reaction with metabolic inhibitors (1, 2) and we have observed inhibition with chymotrypsin substrates and inhibitors (3), enhancement of the in vitro anaphylactic reaction has not been previously reported. While evaluating c-amino caproic acid, an inhibitor of plasminogen activation (4, 5), for its effect on the ana...

Acetylsalicylic acid (ASA) is a nonsteroidal anti-inflammatory drug that can cause mast cell dependent diseases in sensitive individuals. ASA induced asthma is believed to be related to an overproduction of cysteinyl leukotriene C4 (LTC4) secondary to cyclooxygenase inhibition. It remains to be elucidated whether and by which mechanisms ASA may also influence systemic anaphylactic reactions. In...

INTRODUCTION The incidence of anaphylactic reactions during anesthesia is between 1:5000 and 1:25000 and it is one of the few causes of mortality directly related to general anesthesia. The most important requirements in the treatment of this clinical condition are early diagnosis and maintenance of vital organ perfusion. Epinephrine administration is generally considered as the first line trea...