Over the last few decades, research on snake venom toxins has provided not only new tools to decipher molecular details of various physiological processes, but also inspiration to design and develop a number of therapeutic agents. Isolated from the venom of Macrovipera lebetina obutusa (MLO), obtustatin represents the shortest known snake venom monomeric disintegrin specific inhibitor of α1β1 i...

The complete sequence characterization of snake venom proteins by mass spectrometry is rather challenging due to the presence of multiple isoforms from different protein families. In the present study, we investigated the tryptic digest of the venom of the viperid snake Sistrurus catenatus edwardsii by a combined approach of liquid chromatography coupled to either electrospray (online) or MALDI...

BACKGROUND Snakes belonging to the Bothrops genus are vastly distributed in Central and South America and are responsible for most cases of reported snake bites in Latin America. The clinical manifestations of the envenomation caused by this genus are due to three major activities-proteolytic, hemorrhagic and coagulant-mediated by metalloproteinases, serine proteinases, phospholipases A2 and ot...

This study was done to determine whether high or low dose of anti-snake venom (ASV) is better in coagulopathy in victims of envenoming by vipers. This retrospective study was conducted on the 154 patients (Mean age ± SD, Range) of viper snake bites who were referred to the emergency ward of Razi Hospital, Ahvaz, Iran over 2 years period (2004 - 2006). According to the treatment dosage the patie...

Background: Snake bite has been associated with high morbidity and mortality. Personnel are at risk of snake bite. This investigation was carried out amongst residents the purpose identifying factors that led to bites recommending preventive measures.Methods: Three cases bitten by a single were investigated retrospectively. Historical data collected area reconnaissance done. The severity enveno...

What is the composition of snake venom?  Snake venom is a cocktail of several different proteins and enzymes  Protein constitute 90% of dry weight of venoms o Proteins include Lethal Polypeptides and Hydrolytic enzymes (Proteases, Nucleases, Peptidases, Lipases, etc) that can either enhance and/or contribute to the toxic effect of the venom o Enzymes cause both local and systemic destruction ...

objective(s): snake venoms contain complex mixture of proteins with biological activities. some of these proteins affect blood coagulation and platelet function in different ways. snake venom toxin may serve as a starting material for drug design to combat several pathophysiological problems such as cardiovascular disorders. in the present study, purification of anticoagulation factor from veno...

Acetylcholinesterase purified from cobra (Naja naja) venom exhibits a serotonin-sensitive aryl acylamidase activity. Both acetylcholinesterase and aryl acylamidase activities co-eluted in column chromatographic procedures (Sephadex G-75 and Zinc-Sepharose), co-migrated on polyacrylamide gel electrophoresis, co-immunoprecipitated by anti-snake venom antibody and showed the same heat denaturation...

Nerve growth factors (NGF's) were purified from mouse submaxillary gland, guinea pig prostate gland, bovine seminal plasma, and venom of Naja naja atra, and their biochemical and immunological properties were compared. The NGF's from the four sources stimulated the maximal response of nerve fiber outgrowth from chick dorsal root ganglia at 10 ng/ml. Two-site enzyme immunoassay (ETA) systems for...

Snake venom ophthalmia is an acute reaction of the ocular surface tissues to venom ejected into the eyes of spitting cobra victims. The condition is uncommon and the victim may be frightful of going blind. However permanent vision loss is rare. This case (40-year-old man) is reported to discuss the management protocol in such cases. Immediate copious irrigation of the eye is the most important ...