with a 3-day history of worsening dysuria and decreased urinary output; he had no additional systemic symptoms. He reluctantly disclosed that on the evening before the onset of symptoms, his girlfriend had inserted beads into his urethra as part of their sexual activity that night. The patient did not know the number or type of beads used. On physical examination, the patient was not in distres...

Parenteral antibiotic therapy for acute bone infections, soft tissue infections and osteomyelitis may result in high serum concentrations, associated with nephrotoxic, ototoxic and allergic complications. After taking these above mentioned disadvantages into consideration, recent investigations have explored the use of antibiotic-loaded biodegradable implants, incorporating antibiotics for pote...

Microencapsulation has become a common technique in the production of controlled release dosage forms. Many results have been reported, concerning the use of alginate beads as controlled release drug formulations. Alginate has a unique gel-forming property in the presence of multivalent cations, in an aqueous medium. Ibuprofen is an excellent analgesic and antipyretic, non-steroidal anti-inflam...

To date, several strategies have been developed to provide local antibiotic therapy in the treatment of osteomyelitis, such as antibiotic-loaded bone cement, antibiotic-impregnated collagen sponges, polymethylmethacrylate beads, antibiotic-loaded bone graft, antibiotic-loaded synthetic bone substitutes, and antibiotic-coated implants. The optimum carrier for local antibiotic therapy has not bee...

Background: Chronic osteomyelitis is a disease usually of infectious origin. The main cause post-traumatic, it affects the bone tissue and surrounding tissue, most frequent causative agent Staphylococcus aureus. affected tibia. Case description: A 42-year-old male with diagnosis chronic tibia osteomyelitis, sequelae previous surgical interventions, multiple antibiotic treatments, ...

Penicillin production by free and agar immobilized Penicillium chrysogenum cells was investigated in a stirred tank reactor. increased two times with cells. In order to verify the oxygen transfer efficiency STR, mass coefficient determined using dynamic gassing out method at end of steady state operation reactor after achieving penicillin production. The (KLa) obtained STR 20% (V/V) beads, 1 VV...

Background: Diabetic foot infections are the most common skeletal and soft tissue in diabetic patients. Oral antibiotics with good oral bioavailability local delivery of form beads being used. In this study, we analysed effectiveness antibiotic-impregnated treating osteomyelitis We also microbiological profile among study groups.Methods: This was a prospective comparative where 60 patients were...