BACKGROUND In this study, we report on the synthesis, radiolabeling, and biological evaluation of two new somatostatin-14 (SS14) analogs, modified with the universal chelator DOTA. We were interested to investigate if and to what extent such radiotracer prototypes may be useful for targeting sst1-5-expressing tumors in man but, most importantly, to outline potential drawbacks and benefits assoc...

PURPOSE Somatostatin receptor (sst) targeting is an established method to image and treat sst-positive tumors. Particularly, neuroendocrine tumors express the receptor subtype 2 in high density, but sst1, sst3, sst4, and sst5 are also expressed to some extent in different human tumors. Currently used targeting peptides mainly have sst2 affinity. We aimed at developing (radio)peptides that bind ...

Geological data for the Early Eocene (56-47.8 Ma) indicate extensive global warming, with very warm temperatures at both poles. However, despite numerous attempts to simulate this warmth, there are remarkable data-model differences in the prediction of these polar surface temperatures, resulting in the so-called 'equable climate problem'. In this paper, for the first time an ensemble with a per...

PURPOSE Molecular imaging and targeted radiotherapy are emerging fields in nuclear oncology. Five human somatostatin receptors (hsstr1-hsstr5) are known to be overexpressed to some degree on various tumors, sstr2 being the most important one. Clinically used somatostatin based radiopeptides target exclusively sstr2. The aim of this study was to develop novel analogues with a broader sstr profil...

Projections of changes in climate extremes are critical to assessing the potential impacts of climate change on human and natural systems. Modeling advances now provide the opportunity of utilizing global general circulation models (GCMs) for projections of extreme temperature and precipitation indicators. We analyze historical and future simulations of ten such indicators as derived from an en...

The fragmentation of Arn+He1000 (n=3,5) is investigated by zero-point averaged dynamics (ZPAD) and compared with recent results on Ar4+He1000 to investigate the influence dopant size. At core ZPAD, effective He-He potentials converged for He1000 ArnHe1000 are found alike which suggests that ZPAD simulations argon-doped helium nanodroplets (HNDs) could restrict obtained pure HNDs. clusters share...

Bile-salt-dependent lipase (BSDL, EC 3.1.1.-) is an enzyme expressed by the pancreatic acinar cells and secreted as a component of the pancreatic juice of all examined species. During its secretion route BSDL is associated with intracellular membranes. This association allows the complete glycosylation of the enzyme or participates in the inhibition of the enzyme activity, which can deleterious...