G17 has growth promoting and antiapoptotic effects on the AR4-2J pancreatic acinar cell line. We previously reported that whereas MAPK regulates G17-stimulation of AR4-2J cell proliferation, Akt mediates the antiapoptotic action of G17. We examined the signal-transduction pathways mediating G17 stimulation of AR4-2J cell growth and survival. G17 activated the small GTP binding proteins Ras, Rac...

A pancreatic acinar cell line, AR4-2J, that expresses a high density of substance P (SP)-binding sites has been identified. SP-binding sites on intact AR4-2J cells were detected with 125I-Bolton-Hunter SP (125I-BHSP). 125I-BHSP binding to AR4-2J cells has an apparent Kd of 40 pm with slow rates of association and dissociation. The number of high affinity binding sites was about 10(4)/cell. Bind...

Degradation of Acid Red 4 (AR4) by photocatalytic processes with TiO2 nanotube arrays (TNTs) of various dimensions was carried out in this study. TNTs was fabricated by the anodization of titanium foil in electrolyte containing fluoride. The dimension and the induced photocurrent of TNTs were determined by a field-emission scanning electron microscopy and a potentialstat/galvanostat, respective...

The control of cell proliferation by gastrin has been investigated in a rat pancreatic tumour cell line, AR4-2J. Exogenous gastrin, 10-12 to 10-8 M, stimulated cell growth of thymidine-synchronised AR4-2J cells cultured over 48 h in serum-free medium. Cell lysates of AR4-2J cells contained an average of 4.5 and 3.5 pg gastrin per 106 cells, when grown in serum-supplemented or serum-free media, ...

The role of the different basic fibroblast growth factor (bFGF) forms on the regulation of pancreatic acinar cancer cells was analyzed on the rat cell line AR4-2J. This cell line expresses bFGF receptors but does not produce bFGF. AR4-2J cells were retrovirally transfected with the wild type or with point-mutated bFGF complementary DNAs in order to obtain the expression of all the bFGF forms (c...

Citation: Alves JMB, Vasconcelos Junior FC, Chaves RR, Silva EM, Servain J, Costa AA, Sombra SS, Barbosa ACB and dos Santos ACS (2016) Evaluation of the AR4 CMIP3 and the AR5 CMIP5 Model and Projections for Precipitation in Northeast Brazil. Front. Earth Sci. 4:44. doi: 10.3389/feart.2016.00044 Evaluation of the AR4 CMIP3 and the AR5 CMIP5 Model and Projections for Precipitation in Northeast Br...

Global Circulation Models (GCMs) contributed to the Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report (AR4) and are widely used in global change research. This paper assesses the performance of the AR4 GCMs in simulating precipitation and temperature in China from 1960 to 1999 by comparison with observed data, using system bias (B), root-mean-square error (RMSE), Pearson...

In the past several decades, the tropospheric westerly winds in the Southern Hemisphere have been observed to accelerate on the poleward side of the surface wind maximum. This has been attributed to the combined anthropogenic effects of increasing greenhouse gases and decreasing stratospheric ozone and is predicted to continue by the Intergovernmental Panel on Climate Change/Fourth Assessment R...