BACKGROUND Several antibodies, also called serological markers, are associated with specific forms, disease behavior and phenotype of inflammatory bowel disease (IBD). AIM Summarize and analyze the evidence of the utility of serologic markers in IBD, making emphasis on their clinical utility and behavior between populations. MATERIAL AND METHODS Relevant articles were located by computer-as...

Withaferin A (WFA) is a steroidal lactone present in Withania somnifera which has been shown in vitro to bind to the intermediate filament protein, vimentin. Based upon its affinity for vimentin, it has been proposed that WFA can be used as an anti-tumor agent to target metastatic cells which up-regulate vimentin expression. We show that WFA treatment of human fibroblasts rapidly reorganizes vi...

Cutaneous vasculitis, interstitial pneumonia with crazy-paving appearance on high-resolution computed tomography, and repeated positive perinuclear anti-neutrophil cytoplasmic antibodies (pANCA) are rarely found together in patients with inflammatory bowel disease in the existing literature. We report the case of a Chinese patient previously diagnosed with cutaneous vasculitis and interstitial ...

We have studied the effect of activation of the c-erbB-2 receptor tyrosine kinase on protein kinase C (PKC) in cultured SKBR-3 human breast cancer cells. Treatment with the agonistic anti-receptor monoclonal antibody TAb 250 induces receptor autophosphorylation and stimulates phospholipase C-gamma 1 (L. K. Shawver et al. Cancer Res., 54: 1367-1373, 1994). TAb 250 induced a rapid and marked tran...

SW-13 cells that lack cytoplasmic intermediate filaments (IFs) were stably transfected with a human vimentin cDNA expression vector. Isolated subclones displayed two prevalent patterns of vimentin distribution as observed by indirect immuno-localization: (1) cytoplasmic filaments characteristic of a vimentin IF network; and (2) a distinct, juxtanuclear focus with limited filamentous extensions....

Rheumatoid arthritis (RA) is a systemic disease affecting mainly joints. Since rheumatoid arthritis is a common and a world wide problem therefore accurate diagnosis of this disease is essential. In the past rheumatoid factor was considered as the only marker for diagnosing this disease; however rheumatoid factor is present in many other disorders and even in up to 15% of healthy population. Fo...

objective: since colposcopy biopsy test plays a significant role in the evaluation of cervix, especially in patients with an abnormal result of pap smear test, therefore, this research study was conducted to compare the results of pap smear and colposcopy directed punch biopsy tests at firoozgar and akbarabady hospitals from 2001 to 2003. materials and methods: this cross-sectional study was ca...

objective(s):there are supportive evidences about the possible role of latent toxoplasma. gondii infections on the behavior and neurologic functions, such as increased dopamine levels in the brain. the aim of this study was to examine anti-toxoplasma activity of aripiprazole that is an atypical anti-psychotic drug in mice. materials and methods: mice were randomly divided into four groups, incl...