Several recent clinical studies have clearly established that rheumatoid arthritis (RA) is a disease identifiable since its early phases, a disease that can be adequately and efficaciously treated provided the therapeutic program can be started early on. To reach the aim of controlling effectively the disease and of leading the patients to live a normal life, several points must be fulfilled. T...

CHEST I 103 I 3 I FEBRUARY, 1993 I Supplement 133$ decreased at day 24(51.11±2.03 to 35.53±2.37; p<O.Ol). In summary, repeated Ag inhalation in primates induced significant changes in airway T cell subsets (CD4/CD8) and T cell activation (IL2R+). Furthermore, these changes (specifically T cell activation, IL2R +) appeared to parallel the pattern of airway eosinophilia (% BAL Eos) and hyperrespo...

The signaling lymphocytic activation molecule (SLAM) family of receptors and the SLAM-associated protein (SAP) family of intracellular adaptors are expressed in immune cells. By way of their cytoplasmic domain, SLAM-related receptors physically associate with SAP-related adaptors. Evidence is accumulating that the SLAM and SAP families play crucial roles in multiple immune cell types. Moreover,...

The number of pathogens that are required to infect a host, termed infective dose, varies dramatically across pathogen species. It has recently been predicted that infective dose will depend upon the mode of action of the molecules that pathogens use to facilitate their infection. Specifically, pathogens which use locally acting molecules will require a lower infective dose than pathogens that ...

BACKGROUND The comparative effectiveness of available targeted immunomodulators for moderate-to-severe psoriasis has not been evaluated. OBJECTIVE To evaluate the comparative effectiveness of targeted immunomodulators for adults with moderate-to-severe plaque psoriasis. METHODS Systematic literature review of placebo-controlled and head-to-head randomized trials of eight targeted immunomodu...

Cancer stimulates macrophage infiltration and encourages angiogenesis, which is necessary for tumor growth and invasion. It seems, that the influence of photodynamic therapy (PDT) on immune cells and immune regulators plays a crucial role in this process. In order to study this effect, the influence of δ-aminolevulinic acid (ALA) PDT on the activity of the murine macrophage J-774A.1 cell line w...

We present the immuno pathogenesis of Lymphomatoid Papulosis associated with mild immuno suppression. The foundation of our observation was based on case reports discussing the development of LyP while concurrently using immune modulators. The medically altered immune state is mirrored by the hormone-induced changes of pregnancy. Furthermore, we explain how the natural progression of pregnancy ...

From the *Biological Carcinogenesis and Development Program, PRI/DynCorp, Frederick, Maryland 21702-1201; the r of Pathology and the Committee on Immunology, University of Chicago, Chicagg Illinois 60637; the gDepartment of Biology, University of California, San Diego, La Jolla, California 92093; the IIDepartment of Biology and Cancer Center, University of California at Berkeley, Berkeley, Cali...

The purpose of this study was to review currently available literature data concerning pathomechanisms of action, indications, treatment efficacy, as well as side effects of nonsteroidal immunomodulators used in dermatology, primarily for the treatment of allergic dermatoses. MEDLINE search was undertaken using the key words "Topical Immunomodulators, Dermatology and Allergy". Full articles, an...

Objectives: Adalimumab is an effective treatment for Crohn’s disease but antibody development may cause loss of response. Concomitant use of an immunomodulator reduces the development of antibodies. We performed a 5-year cross-sectional study of variation in use of adalimumab and concomitant therapy in a large pediatric population. Methods: We identified patients with Crohn’s disesae aged <18 y...