OBJECTIVE To investigate the role in bipolar disorder of the C9ORF72 hexanucleotide repeat expansion responsible for frontotemporal lobe dementia and amyotrophic lateral sclerosis. METHODS Eighty-nine subjects from a previously described panel of individuals with bipolar disorder ascertained for genetic studies were screened to detect expansion of the C9ORF72 repeat. One two-generation family...

Bipolar disorder is a recurrent and episodic illness. This survey study assessed experiences and identified clinical insights of individuals with bipolar disorder. An Internet-based monitor system database was screened for patients with bipolar disorder in Japan (February and March 2013). Of 1,050 patients, 457 completed surveys, and results were analyzed with descriptive statistics. Approximat...

n contrast to the relationship between substance abuse and bipolar disorder, the relationship between bipolar I disorder and anxiety disorders is vastly underexplored, underappreciated, and certainly understudied. This inattention is surprising in light of the fact that anxiety disorders have the highest rate of comorbidity with bipolar disorder , exceeding the comorbidity rate even of substanc...

background : the existing evidence about the clinical situations of the bipolar patients with opioid dependence is scarce. the present study was carried out to compare the clinical features and course of the bipolar disorder type i regarding the two subgroups of opioid dependent and non-dependent. methods : there were 178 adult patients with bipolar disorder type i consecutively referred to the...

Background: Mood disorders are the most common psychiatric comorbidities in substance users. Mood disorders and substance use disorders are 2 intertwined processes in which treating one aid in treating the other. Depression and substance use disorder are now regarded as major mental health issues due to their widespread incidence. The study was designed to investigate the prevalence of major ...

BACKGROUND Researchers have linked bipolar disorder to elevations in reward sensitivity and positive affect. Little is known, however, about how people with bipolar disorder respond to rewards and positive affect and how these tendencies relate to functioning or quality of life. METHODS Persons diagnosed with bipolar I disorder and matched controls completed the Responses to Positive Affect (...