Although the geroprotectors discovery is a new biomedicine trend and more than 200 compounds can slow aging and increase the lifespan of the model organism, there are still no geroprotectors on the market. The reasons may be partly related to the lack of a unified concept of geroprotector, accepted by the scientific community. Such concept as a system of criteria for geroprotector identificatio...

Recently a cluster of new hypotheses of aging has been suggested, which explicitly predict the importance of early-life events in health and life span modulations. It has been widely assumed that these long-lasting consequences of early-life exposures may depend on the same mechanisms as those underlying "cellular memory," that is, epigenetic inheritance systems. There is a growing body of evid...

Intervention studies in animals suggest molecular changes underlying age-related disease and disability can be slowed or reversed. To speed translation of these so-called "geroprotective" therapies to prevent age-related disease and disability in humans, biomarkers are needed that can track changes in the rate of human aging over the course of intervention trials. Algorithm methods that measure...

Background: Gastrointestinal (GI) malignancies are the most common cancers and account for nearly half of all cancer-related deaths in Iran. There was a strong association between human papillomavirus (HPV) infection and urogenital cancers, in particular the cervix. However, there is no clear causal relationship in all types of cancers, including gastrointestinal cancers. Therefore, the present...

Background: Infertility is an important and common problem in couples that needs to assisted reproductive technology (ART) or the other drug therapies. Infertility has been known as a risk factor for ovarian cancer, breast cancer and endometrial cancer but there is a question about the relationship of these cancers to infertility itself or drugs and methods of infertility treatment. Materials a...

Introduction. Geroprotectors are biologically active substances that inhibit the aging process. Many plant species natural geroprotectors. For instance, Thymus vulgaris and Trifolium pratense callus cultures with strong geroprotective properties.
 Study objects methods. The present research featured T. grown in vitro on various nutrient media. Their extracts were obtained by aqueous-alcoho...