One important complication of diabetes mellitus is chronic, non-healing diabetic foot ulcers (DFUs). This study aims to develop and use dressings based on chitosan derivatives for the sustained delivery of neurotensin (NT), a neuropeptide that acts as an inflammatory modulator in wound healing. Three different derivatives, namely N-carboxymethyl chitosan, 5-methyl pyrrolidinone chitosan (MPC) a...

Avermectin-grafted-N,O-carboxymethyl chitosan (NOCC) derivative was obtained by esterification reaction using dicyclohexylcarbodiimide (DCC) as dehydrating agent and 4-methylaminopyridine as catalyst. The structures of the conjugate were confirmed by FT-IR, (1)H NMR, and XRD. Insecticidal activities against armyworms, carmine spider mites, black bean aphids, and brown plant hoppers were investi...

Abstract The focus of this research was to study the effect combining nanofillers with different geometry and surface chemistry on structure properties biopolymers as an alternative traditional plastics. How inclusion 2D graphene oxide (GO) or reduced GO (rGO) combined 1D sepiolite (SPT) cellulose nanocrystals (CNCs) affect chitosan chitosan/carboxymethyl (CMC) materials investigated. A 3D inte...

We report on optimized architectures containing layer-by-layer (LbL) films of natural rubber latex (NRL), carboxymethyl-chitosan (CMC) and magnetite (Fe3O4) nanoparticles (MNPs) deposited on flexible substrates, which could be easily bent by an external magnetic field. The mechanical response depended on the number of deposited layers and was explained semi-quantitatively with a fully atomistic...

This paper describes the development and testing of two compositions biodegradable soft bait fishing lures. A water-soluble form chitosan, known as carboxymethyl was added to lure formula investigate if properties, such tensile strength, swelling, underwater performance, could be improved. three-month shelf-life study completed compare properties baits: first composition containing no chitosan ...

In this work we developed metformin loaded O-carboxymethyl chitosan (O-CMC) nanoparticles (NPs) by ionic-gelation method. The prepared NPs of 240 ± 50 nm size with spherical morphology exhibited a pH sensitive release of metformin in vitro. Cytotoxicity studies showed that the drug-incorporated NPs induced significant toxicity on pancreatic cancer cells (MiaPaCa-2) compared to normal cells (L92...