The objective of this study was to assess the effect of Vitex agnus castus (VACS) extract in the alleviation of the symptoms of premenstrual syndrome. The study was designed as a double-blind, placebo controlled trial in two parallels groups (15 patients each). Treatment phase lasted 3 consequent menstrual cycles (2*30 drops/day=1.8 ml of VACS) or placebo. For assessment of the efficacy visual ...

In the twentieth century, a whole teaching of mastopathy was formed. However, over time, accumulated data have questioned existence as separate nosological form, because term “fibrocystic disease” while mastalgia is most common symptom does not correspond to holistic concept disease. This “disease” can be diagnosed in any woman and more or less successfully treated. United States, this obsolete...

BACKGROUND AND OBJECTIVES Essential oils are volatile compounds that have been used since Middle Ages as antimicrobial, anti-inflammatory, sedative, local anesthetic and food flavoring agents. In the current study, essential oils of Pelargonium graveolens L'Her and Vitex agnus-castus L. were analyzed for their antibacterial activities. MATERIALS AND METHODS The chemical compositions of essent...

Many women with PMS use alternative therapies, although there has been little research to demonstrate their efficacy. This systematic review provides a comprehensive discussion of dietary supplements and herbal remedies commonly used for premenstrual syndrome (PMS), including calcium, magnesium, vitamin B6, evening primrose oil, Vitex agnus castus, ginkgo biloba and St John’s Wort. Randomized c...

OBJECTIVE To evaluate the effectiveness of a phytotherapeutic intervention comprising a combination of Hypericum perforatum (St. John's wort) and Vitex agnus-castus (Chaste tree/berry) in the management of menopausal symptoms. DESIGN A double-blind, randomized, placebo-controlled, parallel trial was performed over 16 weeks in 100 eligible late-perimenopausal or postmenopausal women experienci...

The effectiveness for vasomotor symptoms and sleep disorders plus the long-term safety of a nutraceutical combination of agnus-castus and magnolia extracts combined with soy isoflavones (SI) and lactobacilli were assessed in postmenopausal women. A controlled study was carried out in menopausal women comparing this nutraceutical combination (ESP group) with a formulation containing isoflavones ...

BACKGROUND Phytoestrogens are plant-derived natural molecules having some bone forming and bone substituting effects. In the present study, the role of phytoestrogens on bone healing was investigated in a rabbit fracture model. METHODS Twenty-two New Zealand white rabbits with right tibia fracture were divided into two groups randomly. The plant derived extract of Vitex agnus-castus L. (Verbe...