There have been many treatments suggested for the management of mastalgia; one of these is the fruit extract of Vitex Agnus castus L. commonly known as Agnus castus, an extract of a deciduous shrub native to Mediterranean Europe and Central Asia. It is postulated that A. castus suppresses the stress-induced latent hyperprolactinemia which is a release of supra-physiological levels of prolactin ...

vitexagnus- castus l. [vac.] has been used in the iranian traditional medicine for the treatment of pain and swelling of uterus. in this study, gc and gc/ms analyses  were carried out for the identification of essential oil chemical components. formalin and xylene-induced ear-edema were used in order to nociception and inflammation activity. then, the possible interaction between 3drugs includi...

Pituitary pars intermedia hyperplasia, which causes Equine Cushing’s Syndrome, has been treated with dopaminergic agonists such as pergolide. Vitex agnus castus (Chaste Berry) extract has been used medicinally for centuries for various human female cycle disorders, and a lay article claimed its therapeutic efficacy in horses with pituitary hyperplasia and other hormonal dysfunction. Ethanol ext...

OBJECTIVES To compare the efficacy and tolerability of agnus castus fruit (Vitex agnus castus L extract Ze 440) with placebo for women with the premenstrual syndrome. DESIGN Randomised, double blind, placebo controlled, parallel group comparison over three menstrual cycles. SETTING General medicine community clinics. PARTICIPANTS 178 women were screened and 170 were evaluated (active 86; ...

Vitex agnus-castus L., (Verbenaceae) traditional Chinese medicinal plant recommended for various inflammatory ailments, but its mechanism of anti-inflammatory action is still unclear. The present study reports the anti-inflammatory activities of various extracts and elucidate possible mechanism(s) with the quantification of flavonoids by RP-HPLC. The petroleum ether, ethyl acetate, methanol and...

Vitex agnus-castus L. (Lamiaceae) is a medicinal plant historically used throughout the Mediterranean region to treat menstrual cycle disorders, and is still used today as a clinically effective treatment for premenstrual syndrome. The pharmaceutical activity of the plant extract is linked to its ability to lower prolactin levels. This feature has been attributed to the presence of dopaminergic...

Resume of 'previous work.?Vaughan (1921) found that an aqueous infusion of the leaves of Vitex peduncularis, Wall, var. roxburghiana, was being used by the aboriginal tribe of Ranchi in malaria and blackwater fever. Though the medicinal properties of the members of the Vitex family (e.g. Vitex trifolia, negundo, etc.) have been elaborately described in the Ayurvedic system of medicine, the Vite...

background: the purpose of this study was to investigate the effects of the combination of vitex agnus castus extract, as a source of phytoestrogens, plus magnesium supplementation on osteogenic and angiogenic factors and callus formation in women with long bone fracture. material and methods: in a double-blind randomized placebo controlled trial, 64 women with long bone fracture,20-45 years ol...

Since the publication of "Application Guideline for Western Traditional Herbal Medicines as OTC Drugs" in 2007, only two European ethnopharmaceuticals, Vitis vinifera L., folium extract (Antistax) and Vitex agnus-castus L., fructus extract (Prefemin), have been approved as OTC drugs in Japan. In this review, we describe the current regulation of Western ethnopharmaceuticals in Japan, summarize ...