Abstract Triple-negative breast cancer (TNBC) is hard to treat because of the development chemoresistance and metastasis. It recently found that combination chemotherapy immune checkpoint blockade can significantly improve TNBC treatment. However, low response rate immunotherapy greatly hampers application TNBC. urgent find new paradigms for We previously transferring thymocytes into Ja281 KO m...

UBE2N (encoded by Ubc13 in mice) is a K63-polyubiqutination-specific E2 conjugase. plays pivotal roles signal transduction and gene regulation. Dysregulation of associated with many immunological disorders as well embryonic developmental defects including loss epidermal integrity. We have previously reported that Rosa-CreER-mediated deletion on adult mouse back skin leads to highly inflamed les...

Treating Central Nervous System (CNS) neuro-inflammational disorders is of great importance. A key aspect of this treatment includes regulation of Cell-Mediated and humoral immune systems. Previous treatment mostly consisted of systemic immunosuppressive drugs. In addition to having adverse side effects, these drugs were also inefficient, such as methotrexate- Cyclophosphamide-Azathioprine. Rec...

Nowadays, growing interest in the application of nanotechnology in biomedical and biotechnological fields has opened a new avenue to explore the nanoparticles-biological system interaction. Indeed, a clear gap is still in the cytotoxic effect of NPs on the biological systems. For this purpose, the interaction of the silica oxide nanoparticles (SiO2-NP) with PC12 cell line, as a model of nervous...

background and objective: garlic has been known worldwide as a dietary constituent with many pharmacological effects. the present in vitro study was designed to investigate the putative anticancer effect of garlic extract on cancer cells, and if this effect was through apoptosis induction. material and methods:  human colon adenocarcinoma cells ht29 were treated with different doses (1, 5 and 1...