The complete amino acid sequence of the mitochondrial ATPase inhibitor peptide was determined. The molecule contains 84 residues of which 40 are charged amino acids that occur in clusters along the chain. A section of the chain, located at the COOH-terminal end, contains several duplicated regions, the most prominent of which are pentapeptides. This section of the chain also contains all of the...

Learning from nature's amazing molecular machines, globular proteins, we present a framework for the predictive design of nanomachines. We show that the crucial ingredients for a chain molecule to behave as a machine are its inherent anisotropy and the coupling between the local Frenet coordinate reference frames of nearby monomers. We demonstrate that, even in the absence of heterogeneity, pro...

We have determined at this point that the DNA molecule may be considered as a long chain of an antiferromagnetic spin adjustment when is accurate to situated on axis supercoil. Furthermore, we examine two polynucleotide chains are coiled regarding same with exact helical sense in molecule, can if specific reference confined coil such contiguous coils reverse direction spin. Actually, each turn ...

The compressibility factor of nonassociated chain molecules composed of hard convex core Yukawa segments was derived with SAFT-VR and an extension of the Barker-Henderson perturbation theory for convex bodies. The temperature-dependent chain and dispersion compressibility factors were derived using the Yukawa potential. The effects of temperature, packing fraction, and segment number on the com...

many anticancer drugs in clinical use interact with dna through intercalation, which is process that starts with the transfer of the intercalating molecule from an aqueous environment to the hydrophobic space between two adjacent dna base pairs. in general, intercalatig agents are two types: monofunctional and bifunctional. monofunctional intercalators contain one intercalating unit and bifunct...

The Kolmogorov-Johnson-Mehl-Avrami equation is wildly applied in the crystallization kinetics, and Avrami exponent involved plays an important role process. Here we show that can be obtained by a fractal model, explained as dimension time, which depends upon chain length molecule weight.

conclusions vancomycin nephrotoxicity is common but usually reversible and has readily manageable adverse effect. urine kim-1 was not more accurate than serum or urine creatinine in detecting vancomycin nephrotoxicity in our study population. results thirteen out of the 52 recruited patients (25%) developed nephrotoxicity, with a mean ± standard deviation onset of 11.46 ± 7.56 days. furosemide ...

The immunopathological functions associated with human C1q are still growing in terms of novelty, diversity, and pathologic relevance. It is, therefore, not surprising that C1q is being recognized as an important molecular bridge between innate and adaptive immunity. The secret of this functional diversity, in turn, resides in the elegant but complex structure of the C1q molecule, which is asse...

mammalians express several subclasses of the igg molecule. in human being there are four homologous igg subclasses, each of which is structurally unique and has different functions. quantification of igg subclasses is fundamental to clinical assessment and diagnosis of many diseases as such assessments depends on the availability of subclassspecific antibodies (abs), particularly monoclonal ant...

An achiral molecular square and a chiral chain composed of cyanide bridged Fe(III) and Ni(II) ions were prepared, and they act as a single molecule magnet and a chiral single chain magnet, respectively.