The pharmacokinetics of p-chloronitrobenzene (p-CNB) in human subjects suffering from acute poisoning was studied from the urinary excretion of p-CNB metabolites. The time course for excretion of five metabolites--2-chloro-5-nitrophenol,N-acetyl-S-(4-nitrophenyl)- L-cysteine, 2,4-dichloroaniline, p-chloroaniline, and 2-amino-5-chlorophenol-were determined by reversed-phase HPLC analysis of urin...

Chloronitrobenzenes (CNBs) are important intermediates for the production of dyes, pesticides, rubber chemicals, and drugs. 2CNB and 4CNB are possible human carcinogens. Therefore, it is important to develop methods to biomonitor people exposed to these occupational and environmental pollutants. We developed a method to determine hemoglobin (Hb) adducts of CNBs. Nitrobenzenes and the resulting ...

The resistance of staphylococci to penicillin depends primarily on the ability of the organism to produce penicillinase (f3-lactamase). In some strains of potentially penicillin-resistant staphylococci, demonstration in vitro of resistance (i.e., of penicillinase production) may require not only prior induction of synthesis of the enzyme but also a highly sensitive method for detecting its pres...

The effects of palladium addition and the reduction methods on Au/TiO2 were investigated. Pd was loaded on TiO2 firstly by incipient-wetness impregnation, Au was then loaded by deposition-precipitation method. The nominal loadings of Au and Pd were 1 wt% and 0.01 wt%. The bimetallic catalysts were reduced by heating at 453 K, by flowing H2 at 423 K, or by NaBH4 at 298 K. The catalysts were char...

Carcinogenicity and chronic toxicity of ortho-ch]oronitrobcnzene (o-CNB) were examined by feeding groups of 50 F344 ruts and 50 BDFI mice of both sexes o-CNB-containing diets for 2 years. The djetary concentration of o-CNB was O, 80, 400 or 2000 ppm (wfw) for rats and O, 100. 500 or 2500 ppm for mice. The 2-year administration of o-CNB produced a dose-dependent increase in incidences of hcpatoc...