normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 introduction: death-related information is source for identifying the health prerequisites and formulating the related programs. due to importance of data for decision making, evaluation of it to determine the rate of documentation and errors is necessary. methods: in this descriptive, cross-sectional study, all issued cer...

Inhibition of the spindle assembly checkpoint kinase TTK causes chromosome mis-segregation and tumor cell death. However, high levels of TTK correlate with chromosomal instability (CIN), which can lead to aneuploidy. We show that treatment of tumor cells with the selective small molecule TTK inhibitor NTRC 0066-0 overrides the mitotic checkpoint, irrespective of cell line sensitivity. In stable...

OBJECTIVE To establish a polymerase chain reaction (PCR)-based clonality assay for archival cervical smears and examine its value in the detection of cervical intraepithelial neoplasia (CIN) and prediction of its clinical behavior. STUDY DESIGN Dyskaryotic cells were microdissected from archival cervical smears of 33 cases and subjected to PCR-based clonality analysis of the androgen receptor...

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OBJECTIVES This study intends to analyze some statistical data concerning Cervical Intraepithelial Neoplasia diagnosed in our hospital. MATERIAL AND METHODS Our study concerning the incidence of Cervical Intraepithelial Neoplasia (CIN) covers the 2000-2009 time-span, the data being collected from the Histopathology Exams (HPE) registers. RESULTS During this period, CIN lesions were discover...

Contrast-induced nephropathy (CIN) (known as contrast-induced acute kidney injury) occurs as a result of acute worsening of renal function following a procedure with administration of iodine contrasts agent and remains a substantial concern in clinical practices. The purpose of this study is to investigate the preventive effect of Pentoxifylline supplementation on reduction of CIN occurrence af...

Fighting cancer is like fighting evolution. its variant genetic background and its easy adaptability made it an exasperating case for science. Today we know that one of the reasons behinds its genetic flexibility is the occurrence of errors during chromosome segregation, a phenomenon also known as chromosome instability (CiN). Until today, it remained unclear if CiN stands at the origin or is a...

Gastric cancer is the fifth most common worldwide and even though its incidence has decreased in Western world, it still fourth cause of cancer-related death. The reason for poor prognosis relates mainly to late diagnosis lack effective treatments metastasized disease. Molecular subtyping was performed according two classifications: A) Cancer Genome Atlas (TCGA) classification into 1) Epstein–B...

Recent developments in molecular cytogenetics allow the detection of genomic rearrangements at an unprecedented level leading to discoveries of previously unknown chromosomal imbalances (zygotic and post-zygotic/mosaic). These can be accompanied by a different kind of pathological genome variations, i.e. chromosome instability (CIN) manifested as structural chromosomal rearrangements and low-le...