BACKGROUND Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting women in the reproductive age group, and is one of the most common causes of hyperandrogenic anovulatory infertility. The aromatase inhibitor, letrozole, has been used for induction of ovulation. The purpose of this study was to compare the effects of letrozole and clomiphene citrate in induction of...

BACKGROUND Endogenous opiates may affect various aspects of reproductive and metabolic function in patients with polycystic ovary syndrome (PCOS). This study evaluated long-term inhibition of the opioid system using naltrexone in clomiphene citrate (CC)-resistant women with PCOS. METHODS A group of 30 infertile females with PCOS were evaluated; all subjects were obese, hyperandrogenic and hyp...

Clomiphene citrate has been traditionally used as the drug of choice in treating women with anovulatory infertility. In the last decade letrozole, an aromatase inhibitor has emerged as alternative ovulation induction agent. Literature confirms that letrozole has a definitive role in anovulatory women who have not responded to the clomiphene therapy. However its role as an alternative to clomiph...

Suzuni, M., TAKAIIASHI, T. and ABE, T. The Effect of Chemical Ovulationinducing Substances on Gonadotropin Secretion is Incubation Experiments of the Anterior Pituitary. Tohoku J. exp. Med., 1972, 108 (2), 123-131 In order to clarify the in vitro action of clomiphene, F6066 and Lychium chinense Miller (LCM) on the pituitary, the anterior pituitary of the rat was incubated with these materials a...

PURPOSE To compare the effects of L-carnitine with clomiphene citrate in idiopathic infertile men. MATERIALS AND METHODS Fifty-two men with idiopathic infertility were recruited in this randomized controlled trial. They were randomly assigned into 2 treatment groups, group 1 (n = 20) and group 2 (n = 32), who received L-carnitine 25 mg/day and clomiphene citrate 2 gr/day, respectively, for a ...

this study was designed to compare the effect of clomiphene and letrozole in ovulatory stimulation in infertile women under intrauterine insemination who referred to mahdiyeh infertility clinic during 2008-2009. 106 infertile women were randomly divided into two equal groups. patients were treated with 5 mg of letrozole daily (in letrozole group) or 100 mg of clomiphene citrate daily (in clomip...

OBJECTIVE  To compare the effectiveness of alternative first line treatment options for women with WHO group II anovulation wishing to conceive. DESIGN  Systematic review and network meta-analysis. DATA SOURCES  Cochrane Central Register of Controlled Trials, Medline, and Embase, up to 11 April 2016. STUDY SELECTION  Randomised controlled trials comparing eight ovulation induction treatme...

background: unovulation is the most common cause of infertility. the first line oral treatment has been clomiphene citrate. another anti-estrogen used for ovulation induction is tamoxifen. many unovulatory infertile women are resistance to anti-estrogens and need another treatment. alternative treatments are aromatas inhibitors. objective: this study was designed to compare the effectiveness of...