Two new TTF-based ligands involving terpyridine moiety (L1=4-(4′-Methyl-phenyl-2,2 : 6’,2’’-terpyridine −4-ylmethylthio)-5-(2-cyanoethylthio)-4′,5′-bis(methylthio)tetrathiafulvene and L2=4-(4′-Methyl-phenyl-2,2 −4-ylmethylthio)-5-(2-cyanoethylthio)-4′,5′-bis(propylthio)tetrathiafulvene) have been synthesized seven related mononuclear complexes were isolated as single crystals. The 2 1 (ligand m...

CoCl2 introduction increased cathepsin G activity in the heart and liver as well as endothelial elastase (EEl) in kidney that indicated the development of destructive processes. CoCl2 introduction decreased EEl and cathepsin G activities in blood serum and cathepsin G in lungs. HgCl2 injection decreased EEl in blood serum, heart, liver, kidney and cathepsin G in blood serum. These decreasing of...

OBJECTIVES The limited homing potential of bone-marrow-derived mesenchymal stem cells (BM-MSC) is the key obstacle in MSC-based therapy. It is believed that chemokines and chemokine receptor interactions play key roles in cellular processes associated with migration. Meanwhile, MSCs express a low level of distinct chemokine receptors and they even lose these receptors on their surface after a f...

Transplantation of tumor xenografts to fertilized chicken eggs is a promising animal replacement method, which has successfully been used for xenotransplantation of pancreatic ductal adenocarcinoma (PDA) cells. PDA is characterized by a pronounced tumor hypoxia, which mediates aggressive growth, therapy resistance and cancer stem cell (CSC) features. For in vivo experimental evaluation of hypox...

Objective(s):The limited homing potential of bone-marrow-derived mesenchymal stem cells (BM-MSC) is the key obstacle in MSC-based therapy. It is believed that chemokines and chemokine receptor interactions play key roles in cellular processes associated with migration. Meanwhile, MSCs express a low level of distinct chemokine receptors and they even lose these receptors on their surface after a...

Purpose: We previously reported that polyploid giant cancer cells (PGCCs) induced by cobalt chloride (CoCl2) exhibit cancer stem cell properties. Daughter cells generated by PGCCs possess epithelial mesenchymal transition (EMT) phenotype changes and EMT plays an important role in cancer development and progression. This study investigated the characteristics of PGCCs from LoVo and HCT116 induce...

Objetivos: Evaluar los cambios morfológicos, proteicos y metabólicos presentados en líneas de COCE sometida a dos modelos hipoxia celular.Métodos: Utilizaremos el método química inducida por cloruro cobalto (CoCl2) modelo variante cubreobjetos. celulares (HACAT, Cal 27, SCC9 e SCC25). 3 grupos experimentales para cada línea celular. Grupo control (normoxia), CoCl2 Los análisis serán realizados ...

The relative importance of environmental hypoxia due to global climate change on organismal ability to adapt to chemical insult and/or mechanisms of these responses is not well understood. Therefore, we have studied the effects of combined exposure to perfluorooctane sulfonamide (PFOSA) and chemically induced hypoxia on membrane lipid profile and homeostasis. Primary salmon hepatocytes were exp...