What can we do? As in other industries that have to deal with complex safety related systems, we will have to apply sophisticated methods to first of all cover and in a second step manage the complexity of signalling systems. Systems engineering is one of those methods that has been successfully applied in other industries to manage the complexity of systems and to develop platform concepts to ...

One of the major challenges in complex systems biology is that of providing a general theoretical framework to describe the phenomena involved in cell differentiation, i.e., the process whereby stem cells, which can develop into different types, become progressively more specialized. The aim of this study is to briefly review a dynamical model of cell differentiation which is able to cover a br...

The theme of this issue of Artiicial Life is that traditional Dynamical Systems theory is inadequate for many problems in the study of Complex Systems. In this paper, I argue that the nite dimensional nature of traditional dynamical systems is inappropriate for evolutionary systems, but that simply embedding the dynamics into an innnite dimensional space overly complicates the mathematics and o...

Developed an integrated intellectual computerized system of ecological-economic monitoring, modeling, and managing the life cycle of the products of technogenic enterprises of transport engineering, which is presented in the form of a 3-equation structure, functioning in conditions of instability. The proposed paradigm system life cycle management applicable to any other control system of large...

comNode classification within Membrane Residue Curves (M-RCMs) currently hinges on Lyapunov’s Theorem and therefore the computation of mathematically complex eigenvalues. This paper presents an alternative criterion for the classification of nodes within M-RCMs based on the total membrane flux at node compositions. This paper demonstrates that for a system exhibiting simple permeation behaviour...

We consider Gabor systems generated by a Gaussian function and prove certain classical results of Paley and Wiener on nonharmonic Fourier series of complex exponentials for the Gabor expansion‎. ‎In particular, we prove a version of Plancherel-Po ́lya theorem for entire functions with finite order of growth and use the Hadamard factorization theorem to study regularity‎, ‎exactness and deficienc...