Background SLFN11 has recently been reported to execute cancer cells harboring replicative stress induced by DNA damaging agents. However, the roles of under physiological conditions remain poorly understood. Germinal center B-cells (GCBs) undergo somatic hypermutations and class-switch recombination, which can cause genotoxic stress. Hence, we tested whether expression needs be suppressed in G...

A preliminary report is given of a trial of the T.R.A.P. regimen (thioguanine, rubidomycin, cytosine arabinoside, and prednisolone) for the treatment of acute myeloid leukaemia. Out of 27 patients treated 13 (48.1%) obtained complete remission. The treatment was well tolerated and produced especially good results in elderly patients.

Consecutive studies of timed sequential therapy were conducted in 44 adults with acute myelocytic leukemia. The rationale was based on evidence that bone marrow prolifer ation in vivo relates temporally to induced humoral stimu latory activities, and on models that demonstrate increased cytotoxicity of cytosine arabinoside to myeloblasts cultured in stimulatory serum. In the initial study (26 p...

The pharmacokinetics of continuous subcutaneous cytosine arabinoside (ara-C) infusions were compared with continuous intravenous infusions. Steady-state serum ara-C levels and myelosuppression were similar with both routes of administration. CSF/serum ara-C ratios ranged from 0.14 to 0.91 (mean, 0.58). Continuous subcutaneous ara-C infusions were a convenient and reliable alternative to intrave...

Sir, Chemotherapy-induced acral erythema (CIAE) is a cytotoxic drug reaction to certain systemic chemotherapeutic agents, such as £uorouracil, doxorubicin, and especially cytosine arabinoside (1). Following discontinuation of chemotherapy, cutaneous lesions subside in 1 ^ 2 weeks with eventual desquamation. Rechallenge of patients with similar chemotherapeutic agents has reproduced the reaction...