Meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. The aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. Meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (PEG) 6000. The effect of solubilization by...

Piroxicam has two different crystalline forms (known as needle and cubic forms), that they are different in physicochemical properties such as biological solubility. In the current research, using Taguchi experimental design approach the influences of five operating variables on formation of the piroxicam polymorph shapes in recrystallization were studied. The variables include type of solvent,...

introduction the iran has vast areas of karst landforms due to the relatively high carbonaceous rocks deposited during different geologic eras. karst landforms are noteworthy for investigation from many aspects. the primary importance of these regions is the considerable amount of underground water stored in karst formations. these reserves are favorable, both in quality and quantity, as natura...

The controlling kinetics of the water solubility of two synthesized mono azo naphthalimide based disperse dyestuffs in the presence of two different dispersing agents namely Irgasol DAM and lyoprint EV agents at various temperatures were investigated. An exponential rate equation was found to describe the dissolution process. The addition of Irgasol DAM and Lyoprint EV dispersing agents increas...

The purpose of the present study was to investigate the effect of polyethylene glycol (PEG) molecular weights (6000, 12000 and 20000) as solid dispersion (SD) carriers on the dissolution behavior of simvastatin. SDs with various drug : carrier ratios were prepared by solvent method and evaluated for dissolution rate. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), infrared spe...

Meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. The aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. Meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (PEG) 6000. The effect of solubilization by...

carbamazepine belongs to the class ii biopharmaceutical classification system (bcs) which is characterized by a high per-oral dose, a low aqueous solubility and a high membrane permeability. the bioavailability of such a drug is limited by the dissolution rate. in order to increase the drug dissolution, its solid dispersions were prepared by the cogrinding technique using an insoluble but highl...

in order to improve particle properties, new processes combining granulation and crystallization are being developed. this work deals with the spherical crystallization process by the quasi-emulsion mechanism applied to carbamazepine, a pharmaceutical drug. the aim of the present study was to produce of spherical grains made of mall crystals of a drug that have adequate properties for direct co...

the in vitro dissolution of plasma-sprayed hydroxyapatite (pha) coatings with different characteristics, produced by various spraying conditions, in a tris-buffered solution at ph 7.4 was experimentally studied through the measurement of calcium ions release with inductively coupled plasma atomic emission spectroscopy (icp-aes), and then modeled. three coating characteristics, the crystallinity...