Objective(s): Studies indicate that major deficiency in the levels of monoaminergic transmitters is a reason for severe depression. On the other hand, it is shown that Carthamus tinctorius L. (CT) may improve neuropsychological injuries by regulation of the monoamine transporter action. Hence, the present study was undertaken to evaluate the involvement of monoaminergic systems in antidepressan...

Objective: To evaluate the possible antidepressant effects of alpha-terpineol in rodents. Material and Methods: Depression levels were analyzed by comparing total immobility time presented animals experimental groups test session, using Forced Swimming Test Tail Suspension Test. The parameters locomotion (central, peripheral total) motor coordination evaluated Open Field Rota Rod Test, respecti...

Aim of the study: Averrhoa bilimbi is used to treat a variety illnesses, including those that affect central nervous system. In this study, albino rats were given methanolic extract leaves (MEAB) investigate its effects using behavioral assays are sensitive antidepressants with clinical efficacy. Methodology: When mice subjected Tail suspension test (TST) and Forced swim (FST), (125,250, 500mg/...

Depression is a state of mood or energy level that includes lack motivation, sense hopelessness and loss physical energy. The World Health Organization revealed depression one the leading causes ill health disability worldwide. More than 300 million people are living with depression. Many currently available antidepressant drugs have proven to be effective but they burdened some disadvantages s...

Inflammatory responses induced by peripheral administration of lipopolysaccharide (LPS) triggers depressive-like behavioral syndrome in rodents. Inhibition of phosphodiesterase 4 (PDE4) produces a robust anti-inflammatory effect in inflammatory cells. Unfortunately, archetypal PDE4 inhibitors cause intolerable gastrointestinal side-effects, such as vomiting and nausea. N-isopropyl-3-(cyclopropy...

Since the increased prevalence of anabolic androgenic steroids abuse in last few decades is usually accompanied by various exercise protocols, the scope of our study was to evaluate the effects of chronic nandrolone decanoate administration in supraphysiological dose and a prolonged swimming protocol (alone and simultaneously with nandrolone decanoate) on depressive state in male rats. Simultan...

Objective(s): Curcumin, a plant alkaloid from Curcuma longa, possess antioxidant and anti-inflammatory properties. Recently, the antidepressant activities of curcumin were reported. Nevertheless, bioavailability of curcumin limits its therapeutic utility. Nanotechnology is a developing field that potentially enhances bioavailability and the plasma concentration of curcumin. This study investiga...

It has been clinically reported that toluene causes mental depression in humans. However, the detrimental effects of toluene exposure on brain function and the relation between features of mental depression and toluene exposure are poorly understood. This study evaluated depression-like behaviors in adult C57BL/6 mice after administration of toluene, and elucidated the effects of classical anti...

Anxiety and depression are multifactorial disorders that have become prominent health problems all over the world. Neurotrophic factors have emerged underlying pathogenesis of these diseases. Although a number of studies indicate that the hippocampus-brain-derived neurotrophic factor (BDNF) may be involved in these psychiatric illnesses, little is known about the molecular mediators of these di...