Increased gastrointestinal motility in mice as one of the withdrawal symptoms of commonly abused drugs like diazepam or morphine and its possible mechanism of action was studied. Male Laka mice (20-25 g) were made addict to either diazepam (20 mg/kg, ip for 7 days) or morphine (10 mg/kg, sc for 9 days). Withdrawal symptoms were noted 24 hr after the last injection of diazepam or morphine. The a...

The drug midazolam has been recommended to replace diazepam as the immediate anticonvulsant treatment for nerve agent-induced seizures. This recommendation marks the latest decision in an ongoing program to improve medical countermeasures to treat nerve agent poisoning. Extensive rodent screening studies first identified midazolam as the most promising compound to focus on for advanced testing....

Introduction Increasing numbers of patients are receiving treatment with the tranquillizing drugs, and patients referred to hospital with suspected thyrotoxicosis are often taking such drugs. It is important to know what effects these drugs have on tests of thyroid function if diagnostic confusion is to be avoided. Diazepam is a commonly prescribed centrallyacting tranquillizer. Published work ...

centrations of diazepam in the blood, but previous studies (7) have shown that a single 10-mg oral dose will, after I to 2 hours, produce concentrations similar to those in patients following a typical dosage regimen of 5 mg, three times daily. This does not imply that shortand longterm diazepam effects will necessarily be the same because of equivalent blood concentrations, nor that healthy vo...

Introduction Increasing numbers of patients are receiving treatment with the tranquillizing drugs, and patients referred to hospital with suspected thyrotoxicosis are often taking such drugs. It is important to know what effects these drugs have on tests of thyroid function if diagnostic confusion is to be avoided. Diazepam is a commonly prescribed centrallyacting tranquillizer. Published work ...

The effect of diethyl pyrocarbonate modification of histidine on the specific binding of [3H]diazepam and its enhancement with muscimol and (+/-)-pentobarbital was investigated. Diethyl pyrocarbonate treatment produced a dose-related inhibition of specific [3H]diazepam binding to rat brain membranes with a maximal inhibition of approximately 40% at 1 mM. Scatchard analysis of the binding data s...

In 42 alcoholic inpatients we performed an open randomized study to compare the effects of diazepam and gamma-hydroxybutyrate (GHB) on the suppression of severe alcohol withdrawal syndrome and hypercortisolism. Both diazepam (.5 mg/kg bodyweight, q.i.d.) and GHB (50 mg/kg bodyweight, q.i.d.) were orally administered for three weeks. During all study period, GHB was more able than diazepam in re...

Experiments using male CD1 mice were carried out to investigate the effects of subchronic (daily administration for 8 days) pretreatments with drugs enhancing GABAergic transmission (diazepam, 10 mg/kg, ip; gabapentin, 100 mg/kg, po; or vigabatrin, 500 mg/kg, po) on pentylenetetrazol (PTZ)-induced seizures, 24 h after the last injection. Subchronic administration of diazepam reduced latencies t...