OBJECTIVE To determine the association between glutathione S-transferase (GST) polymorphisms and the risk of differentiated thyroid carcinoma (DTC) and benign thyroid tumors. DESIGN Case-control study. SETTING Tertiary care cancer center. PATIENTS Two hundred one patients with DTC, 103 patients with benign thyroid tumors, and 680 cancer-free control subjects. MAIN OUTCOME MEASURES Resul...

objective: the current study aimed to determine the efficacy of radioiodine-131 (131i) ablation therapy with thyroid hormone replacement one day before 131i administration in patients with well-differentiated thyroid cancer (dtc). methods: this retrospective study included 29 patients who underwent 131i therapies twice for dtc during 6-12 months.  since all the patients obviously had residual l...

Purpose: To investigate the prognostic value of serum-stimulated thyroglobulin (ps-Tg) before first 131I therapy in patients with metastatic radioactive iodine-refractory differentiated thyroid cancer (RR-DTC). Methods: From August 2017 to 2020, clinical data for 160 papillary carcinoma (PTC) who received thyroidectomy and treatment were analyzed retrospectively. Differences related indices com...

BACKGROUND The incidence of differentiated thyroid carcinoma (DTC) is low in people of African origin and higher in populations living on islands, but there is no well-established explanation for these differences. Cuba is a multiethnic nation with people of African and Spanish descent. Until now, no study on the risk factors of DTC has focused on the Cuban population. Our aim is to establish t...

OBJECTIVE To evaluate several metabolic changes in patients with differentiated thyroid carcinoma (DTC ) which enhance cardiovascular risk in the western region of Nepal. MATERIALS AND METHODS This hospital based case control study was carried out using data retrieved from the register maintained in the Department of Biochemistry of the Manipal Teaching Hospital, Pokhara, Nepal between 1st Ja...

INTRODUCTION Differentiated thyroid carcinomas (DTC) have good prognoses after complete resection. Nevertheless, when DTC is associated with an aerodigestive invasion, curative surgery is difficult to perform. However, there is no established neoadjuvant therapy for advanced DTC. PRESENTATION OF CASE A 73-year-old man with thyroid papillary carcinoma was referred to our hospital. A computed t...

Along with breast and endometrial cancers, thyroid cancer is a major component cancer in Cowden syndrome (CS). Germline variants in SDHB/C/D (SDHx) genes account for subsets of CS/CS-like cases, conferring a higher risk of breast and thyroid cancers over those with only germline PTEN mutations. To investigate whether SDHx alterations at both germline and somatic levels occur in apparently spora...

INTRIDUCTION The reported prevalence of chronic autoimmune thyroiditis associated with differentiated thyroid cancer (DTC) is heterogeneous.The aim of this study was to evaluate some epidemiological, clinical, sonographical and histological features of operated thyroidnodules with background diffuse autoimmune thyroiditis. MATERIAL AND METHODS The study included 411 cases with Hashimoto's thy...

Thyroglobulin antibody (TgAb) has been used as a surrogate tumor marker of differentiated thyroid carcinoma (DTC) patients. Preoperative TgAb (PreopTgAb) is thought to affect the prevalence, disease severity, and outcome DTC. The objective present study was retrospectively analyze prevalence PreopTgAb in patients diagnosed with DTC its relation cancer characteristics, staging, outcome. A retros...

BACKGROUND Thyroglobulin (Tg) antibodies (TgAb) screening is recommended in patients with differentiated thyroid carcinoma (DTC) to validate Tg measurements. We compared a new multiplexed and 2 conventional TgAb immunoassays in patients with DTC and healthy controls. METHODS TgAb were measured by 2 conventional automated immunoassays and a multiplexed immunoassay in sera from 163 patients wit...