Stimulation of lipolysis or adenylate cyclase activity by either isoprenaline or a tumor-derived lipid-mobilizing factor was effectively attenuated in isolated white adipocytes or in adipocyte plasma membranes pretreated with eicosapentaenoic acid (EPA) dissolved in ethanol or from mice dosed p.o. with EPA (1.25 g/kg). A similar effect was observed with docosahexanoic acid (DHA) that may be par...

Omega-3 polyunsaturated fatty acids (n-3 PUFAs), particularly eicosapentanoic acid (EPA) and docosahexanoic acid (DHA), has been acknowledged as essential very long-chain fatty acids contributing to either achieving optimal health or protection against diseases, and even longevity. Recent high impact studies dealing with EPA and DHA have sparked a renewed interest in using n-3 PUFAs for cancer ...

Transmembrane ion transport by arachidonic acid (AA) through bilayer lipid membranes (BLMs) was investigated by means of electrochemical measurements to provide a basis for designing a sensor membrane. We found that AA induces a channel-type current, in addition to a carrier-type current, across planar BLMs. A linear relation between the logarithmic value of the AA concentration and the current...

OBJECTIVES Celiac disease (CD), a genetically predisposed intolerance for gluten, is associated with an increased risk of major depressive disorder (MDD). We investigated whether dietary intake and serum levels of the essential n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexanoic acid (DHA) found in fatty fish play a role in this association. METHODS Cross-sec...

SCOPE Pancreatic cancer remains a disease of poor prognosis, with alternate strategies being sought to improve therapeutic efficacy. Omega-3 fatty acids have shown clinical benefit, and mechanisms of action are under investigation. METHODS AND RESULTS Proliferation assays, flow cytometry, invasion assays, ELISA and western blotting were used to investigate efficacy of omega-3 fatty acids alon...

Specific fatty acids and sterols in food composites from seven countries were analyzed. In the 1960s, groups of 8 to 49 men from 16 cohorts, ages 40–59 years and living in the United States, Finland, the Netherlands, Italy, Greece, the former Yugoslavia, or Japan recorded their food intake. In 1987, we collected food composites representing the average food intake per cohort sample in the 1960s...

Inflammatory bowel diseases are life-long reoccurring inflammatory disorders of the gastrointestinal tract and have been increasing in incidence in recent decades, notably in the pediatric population. Although genetic predisposition remains an important factor, this increased incidence most likely reflects an environmental change. One potential contributor to this is the change in dietary fat i...

The euryhaline copepod Pseudodiaptomus inopinus play important roles in coastal waters as vectors of docosahexanoic (DHA) and eicosapentaenoic (EPA) acids for larval fish. While DHA EPA polar lipids (PLs) are more effective fish development than non-polar lipid forms (NLs), there is little knowledge how much these accumulated copepods from microalgae early larvae. We report PLs fatty acid profi...

Various studies have demonstrated the impact of omega-3 fatty acids on the concentration of C reactive protein (CRP), pro-inflammatory eicosanoids, cytokines, chemokines and other inflammatory mediators. Therefore, the supplementation of these types of lipids may represent additional option treatment for chronic systemic diseases, such as Systemic Lupus Erythematous and other rheumatic diseases...