Graphene has excellent properties which can be a promising material as nanocomposites for application in drug delivery system (DDS). In this study, reduced graphene oxide/silver nanoparticles (rGO/AgNPs) was synthesized using facile in-situ method loading of acetylsalicylic acid (ASA). The synthesis results were characterized by FESEM, EDX, UV-Vis, XRD, and Raman spectrophotometers analyses. sh...

cyproterone acetate (ca) has been loaded to liposome by solvent evaporation and thin film formation technique. the effects of some formulation variables such as temperature of organic solvent evaporation, rotary evaporator speed, volume of organic solvent, volume of balloon and temperature of hydrating buffer has been evaluated. the data showed that bigger balloon with higher surface area has b...

alpha-1antitrypsin (a1at) deficiency, an inherited disorder, has been shown to be the cause of lung diseases such as emphysema and chronic obstructive pulmonary disease. one of the treatment strategies to provide appropriate and adequate concentrations of a1at in the lungsis the application of nanoparticles (nps) in pulmonary drug delivery. in the current study, biocompatible nanohydrogels were...

Defined aggregates of polymers such as polymeric micelles are of great importance in the development of pharmaceutical formulations. The amount of drug that can be formulated by a drug delivery system is an important issue, and most drug delivery systems suffer from their relatively low drug-loading capacity. However, as the loading capacities increase, i.e., promoted by good drug-polymer inter...

The goal of "treatment on demand" is to allow all those seeking substance abuse treatment immediate entry into a program. Surprisingly, little is understood regarding the relationship between the demand for treatment, queues, waiting times and treatment admission rates, and treatment capacity. Nor has the increase in treatment capacity required to eliminate drug treatment queues, along with the...

the present study deals with the formulation and evaluation of chitosan nanoparticles containing donepezil hydrochloride for the targeted delivery to the brain. nanoparticles were prepared by ionic gelation method using sodium tripolyphos-phate (tpp) as a cross linking agent followed by sonication. nanoparticles were obtained in the average size ranging from 116.8 to 227.5 nm. particle morpholo...

tilmicosin (tlm) is an important antibiotic in veterinary medicine with low bioavailability and safety. this study aimed to formulate and evaluate physicochemical properties, storage stability after lyophilization and antibacterial activity of three tlm-loaded lipid nanoparticles (tlm-lnps) including solid lipid nanoparticles (slns), nanostructured lipid carriers (nlcs) and lipid-core nanocapsu...