no difficulty was experienced in injecting the solution with a 10 c.c. glass serum syringe. The veins of the arm were constricted by a bandage or the hand of an assistant and the forearm massaged upwards until the veins became prominent. The needle was pushed into the vein and a little blood allowed to flow into the syringe to make certain that the needle was in the vein. After the solution had...

Dear Sir,?As the subject of poisoning by Tartar Emetic is at present creating a good deal of discussion in connection with the recent " Bravo case," I trust the following account of poisoning by this drug may prove sufficiently interesting to merit publication. On the 7th of April last at 2-30. P.M., a respectable young Eurasian, a student, was brought to this hospital in a greatly exhausted an...

The increasing interest of improving patients outcome in terms of survival and response, seems to underlie the lack of attention to the anti-emetic prophylaxis. Many clinicians maybe believe that CINV constitutes a “minimal” price to pay for survival gain. On the other hand, patients frequently do not discuss chemotherapy-related side effects, since they may believe that these effects are an ex...

Emetic responses to cisplatin and participation of vagal innervation in emesis were studied in suncus. Intraperitoneal and intravenous administration of cisplatin caused dose-dependent emesis. ED50 values, latencies and frequencies were not significantly different between the two administrations. Cis-diaqodiammineplatinum (DAP), an active metabolite of cisplatin, also induced emesis, but with s...

Uses Actions Fentanyl is a potent narcotic analgesic with a rapid onset and short duration of action. The principal actions of therapeutic value are analgesia and sedation. At a dose of 100 micrograms (2 mL), the analgesic activity of fentanyl is approximately equivalent to 10 mg of morphine or 75 mg of pethidine. Fentanyl differs from morphine by its short duration of analgesic activity, lack ...

Althesin, the new steroid anaesthetic, has been given to patients having minor gynaecological operations after six different premedicant combinations. Atropine, which had been studied previously, was a satisfactory premedicant in terms of both induction and recovery and diazepam 10 nag was not very different. Hyoscine, given before Althesin 50 /"I/kg, increased the incidence of involuntary musc...

Though elevated to the dignity of book-form this reprint of Dr. Hare's address to the Metropolitan Counties Branch of the British Medical Association would, in respect of quantity, more fittingly have been issued as a brochure. But, voluminous though it be not, it yet affords food for reflection upon the mutability of fashion in medical treatment. Dr. Hare's experience and knowledge are extensi...

It has been suggested that there may be some advantage in pre-emptive administration of analgesics, which may be of some relevance in day-surgery. Post-operative pain control is often difficult due to the reluctance to use potent analgesics, whose side effects include nausea and vomiting, which are an important cause of delayed discharge. In order to test the potential beneficial effects of pre...

Neuroleptic malignant syndrome is considered as a rare but potentially fatal complication of neuroleptic medications e.g.,antipsychotics, sedatives and anti emetics. It is characterized by hyperthermia, muscle rigidity, an elevated creatine kinase level and autonomic instability. The syndrome often develops after the start of antipsychotic or a sudden increase in dosage of the neuroleptic medic...