cytokines or tumor-related proteins) which circulate in the bloodstream, affecting the function of other tissues at a site distant from the tumor origin. The prevalence of HCC-related paraneoplastic erythrocytosis ranges from 1% to 3%.[1,2] The underlying pathophysiology of HCCrelated paraneoplastic erythrocytosis is multifactorial. Firstly, local hypoxia from focal hepatic tumor necrosis leads...

Several etiologies have been proposed for erythrocytosis associated with uterine leiomyoma. We report a case of erythrocytosis associated with a large uterine leiomyoma, in which specific immunostaining for erythropoietin was positive. A 55-year-old woman, gravida 0, para 0, was referred to our hospital for treatment for a large uterine myoma and erythrocytosis. She had no vaginal bleeding afte...

sunitinib is an oral tyrosine kinase inhibitor which prevents tumor growth and metastatic progression. it was approved for treatment of advanced renal cell cancer, gastrointestinal stromal tumor and advanced pancreatic neuroendocrine tumors. it has several adverse reactions on multi organ systems including hematologic system. although the neutropenia and thrombocytopenia commonly happens as gra...

OBJECTIVE To examine the relationship between hematologic parameters at birth and prenatal progression of Doppler abnormalities in fetal growth restriction (FGR). METHODS The study was a secondary analysis of FGR patients (abdominal circumference < 5th percentile and umbilical artery pulsatility index (UA-PI) elevation) with at least three examinations prior to delivery. Prenatal progression ...

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a hypersensitivity reaction. Therefore, the case of 51-year-old woman no history drug allergies presented. In empirical treatment Ceftriaxone, presenting 15 days later pruritic maculopapular rash on chest, abdomen extremities accompanied by temperature rises up to 39°C. Laboratories leukocytes 47.38/uL, eosinophils 27.07/uL, skin ...

Graves' disease (GD) is associated with various hematologic abnormalities but pancytopenia and autoimmune hemolytic anemia (AIHA) are reported very rarely. Herein, we report a patient with GD who had both of these rare complications at different time intervals, along with a review of the related literature. The patient was a 70-year-old man who, during a hospitalization, was also noted to have ...

BACKGROUND This study aimed to evaluate the clinical features of posterior reversible encephalopathy syndrome (PRES) in children. METHODS The medical records of 31 patients from five medical centers who were diagnosed with PRES from 2001 to 2013 were retrospectively analyzed. In the 31 patients, 16 were males, and 15 females, with a median age of 7 years (3-12 years). Patients younger than 10...

Adults with bleeding disorders may present to their family physician with minor bleeding symptoms or hematologic laboratory abnormalities discovered during evaluation for surgery or another purpose. Identifying the small proportion of adults who have an underlying bleeding disorder as the cause for such signs or symptoms may be challenging. In cases of asymptomatic hematologic laboratory abnorm...

CE Email comments/questions to [email protected], fax 800-556-3288, or log on to www.VetLearn.com Erythrocytosis in dogs and cats has various causes. Relative erythrocytosis is associated with a normal red blood cell (RBC) mass, whereas absolute erythrocytosis (primary and secondary) is characterized by increased numbers of RBCs. Primary erythrocytosis is a rare myeloproliferative diseas...

A subset of patients with familial platelet disorder with propensity to myeloid malignancy and germline RUNX1 mutation develops hematological malignancies, often myelodysplastic syndrome/acute myeloid leukemia, currently recognized in the 2016 WHO classification. Patients who develop hematologic malignancies are typically young, respond poorly to conventional therapy, and need allogeneic stem c...