introduction:patients with cyanotic heart disease may have an acceptable quality of life. however, they are invariably prone to several complications. the aim of this study is search about hematologic abnormalities in cyanotic congenital heart disease patients. materials and methods:  in this cross sectional study every cyanotic congenital heart disease patients who was referred to the adult co...

Introduction:Patients with cyanotic heart disease may have an acceptable quality of life. However, they are invariably prone to several complications. The aim of this study is search about hematologic abnormalities in cyanotic congenital heart disease patients. Materials and Methods:  In this cross sectional study every cyanotic congenital heart disease patients who was referred to the adult co...

JAK2 exon 12 mutations were detected in 4 out of 20 polycythemia vera and idiopathic erythrocytosis V617F-negative patients and were only present in the myeloid lineage. Initial hematologic data of these patients differ from those of V617F-positive patients, but there is no difference in thrombotic development and myelofibrotic transformation.

BACKGROUND AND OBJECTIVES Idiopathic erythrocytosis (IE) is characterized by erythrocytosis in the absence of megakaryocytic or granulocytic hyperplasia, and is associated with variable serum erythropoietin (Epo) levels. Most patients with IE lack the JAK2 V617F mutation that occurs in the majority of polycythemia vera patients. Four novel JAK2 mutant alleles have recently been described in pat...

Philadelphia-negative classical myeloproliferative neoplasms (MPNs) include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). The 2016 revision of the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues includes new criteria for the diagnosis of these disorders. Somatic mutations in the 3 driver genes, that is, JAK2, CALR, and MPL, represe...

OBJECTIVES Cocaine-mediated erythrocytosis is one of several effects that cocaine may have on hematologic indices; however, the precise mechanism by which cocaine induces peripheral erythrocytosis is not fully understood. The objective of this study was to examine the contribution of the bone marrow to cocaine-mediated erythrocytosis. METHODS Differences in mean hemoglobin concentration, hema...

A descriptive study was carried out in the Emergency Department of Punjab Institute Cardiology, Lahore, from Oct 2022-April 2023 to assess incidence 30 days mortality STEMI patients with varying hematocrit levels. total 440 cases ST-segment elevation MI levels (anemia and erythrocytosis) were included study. In our study, average age 44.12+10.16 years, 273 (62%) male, 167 (37.9%) females; frequ...