RUNX1/ETO, the fusion protein resulting from the chromosomal translocation t(8;21), is one of the most frequent translocation products in acute myeloid leukemia. Several in vitro and in vivo studies have shown that the homo-tetramerization domain of ETO, the nervy homology region 2 (NHR2), is essential for RUNX1/ETO oncogenic activity. We analyzed the energetic contribution of individual amino ...

BAE Systems Naval Ships has undertaken a comprehensive overhaul of all aspects of its approach to the engineering, design and manufacture of complex warships. Through a partnership with the University of Strathclyde, research has been completed on the implementation of Product Lifecycle Management (PLM) to meet organisational objectives in the development of Engineer to Order (ETO) products. En...

AML1-ETO, a chimeric gene frequently detected in acute myelogenous leukemia (AML), inhibits the differentiation of myeloid progenitors by suppressing genes associated with myeloid differentiation and increases the replating ability of clonogenic myeloid progenitors. However, AML1-ETO alone cannot induce AML and thus additional genetic events are required for the onset of AML. The Wilms tumor ge...

The Class A pan coefficient (Kp) has been used to convert pan evaporation (ECA) to grass-reference evapotranspiration (ETo), an important component in water management of irrigated crops. There are several methods to determine Kp values, using wind speed, relative humidity and fetch length and conditions. This paper analyses the following methods to estimate Kp values: Doorenbos & Pruitt (1977)...

E2A is a member of the E-protein family of transcription factors. Previous studies have reported context-dependent regulation of E2A-dependent transcription. For example, whereas the E2A portion of the E2A-Pbx1 leukemia fusion protein mediates robust transcriptional activation in t(1;19) acute lymphoblastic leukemia, the transcriptional activity of wild-type E2A is silenced by high levels of co...

We investigated the effects of the fatty acid oxidation inhibitor etomoxir (ETO) on food intake and on fat and carbohydrate metabolism in two double-blind crossover studies in male, normal-weight subjects. In study 1, ETO (75 mg [+]-racemate) or placebo was given orally 30 min after completion of a standardized, fat-enriched (total energy: 2698 kJ, 40% from fat) lunch. The subjects (n = 15) wer...

Global warming due to greenhouse effect is expected to cause major changes in climate of some regions. The change of climate is likely to have a profound effect on hydrological cycle. Evapotranspiration (ET, as the major component of hydrological cycle, will affect crop water requirement and future planning and management of water resources. This study was conducted to investigate climate chang...

Trend analysis and estimation of monthly and annual precipitation, reference evapotranspiration ETo, and rainfall deficit are essential for water-resources management and cropping-system design. Rainfall, ETo, and water-deficit patterns and trends at Macon in eastern Mississippi for a 120-yr period (1894–2014) were analyzed for annual, seasonal, and monthly periods. The analysis showed historic...

General Engineer-to-Order (ETO) design of product capacity projects among many others, includes design for large electric machine, huge centrifugal pumps, diesel/natural fuel power plant engines, steam turbine, boiler, ship power, et cetera. ETO is basically a product development process, which starts with a product specification and finishes with an engineering design as its deliverable. It ra...