نتایج جستجو برای: functionalized piperidines

تعداد نتایج: 21966  

Journal: :Journal of medicinal chemistry 2000
A P Tamiz J Zhang J L Flippen-Anderson M Zhang K M Johnson O Deschaux S Tella A P Kozikowski

The synthesis and monoamine transporter activity of additional members of a series of 3,4-disubstituted piperidines (truncated analogues of the WIN series) are described. All members of this series were prepared from arecoline hydrobromide in optically pure form and were evaluated for their ability to inhibit high affinity uptake of dopamine (DA), serotonin (5-HT) and norepinephrine (NE) into r...

This paper investigated the effect of the amine-functionalized carbon nanotubes (CNTs) on the thermomechanical properties of CNT/epoxy nanocomposites. Mechanical stirring and ultra-sonication were utilized to uniformly disperse CNTs into the epoxy matrix. Non-functionalized and amine-functionalized CNTs with different weight percentages (wt. %) were mixed into the epoxy resin. Using standard te...

Highly substituted piperidines were synthesized via the condensation of aromatic aldehydes and aromatic amines with β-ketoesters in the presence of antimony(III) chloride at ambient condition. This reaction has any advantages such as easy work-up, clean procedure, and good yields.

2012
Pavol Jakubec Dane M Cockfield Madeleine Helliwell James Raftery Darren J Dixon

A versatile nitro-Mannich/lactamisation cascade for the direct stereoselective synthesis of heavily decorated 5-nitropiperidin-2-ones and related heterocycles has been developed. A highly enantioenriched substituted 5-nitropiperidin-2-one was synthesised in a four component one-pot reaction combining an enantioselective organocatalytic Michael addition with the diastereoselective nitro-Mannich/...

Journal: :Organic & biomolecular chemistry 2012
Matthew O'Brien Andrew Leach Roly J Armstrong Keting Chong Ross Sheridan

Utilising the propensity of the 2-furanyl group to facilitate equilibration of an adjacent tosylamide chiral centre, a diastereoselective route to 2,6-syn-piperidines was developed that proceeds with high levels of thermodynamic stereocontrol. X-ray crystallography structures suggest that, as seen in similar systems, pseudo-allylic strain between the N-tosyl group and the substituents at the 2 ...

Journal: :iranian journal of chemistry and chemical engineering (ijcce) 2015
hongbo xu dan-dan liu lu he na liu guiling ning

the poly(ethyleneimine)-functionalized silica has been developed successfully as an effective adsorbent for the adsorption removal of cu(ii) ions from electroplating wastewater. the influences of ph, contact time and initial concentration of cu(ii) ions on the adsorption capacity and the effect of adsorbent dosage on the removal efficiency of cu(ii) ions from electroplating wastewater were inve...

Journal: :Organic & biomolecular chemistry 2015
Ramu Petakamsetty Vipin Kumar Jain Pankaj Kumar Majhi Ramesh Ramapanicker

A very efficient route to the diastereoselective synthesis of polyhydroxy pyrrolidines, piperidines and azepanes from an aldehyde derivative of ribose is reported. Asymmetric α-amination of aldehydes using proline catalysed hydrazination is the key step in the synthesis. The method utilizes the stereocenters present in ribose and the extra carbon atoms present in the target molecules are incorp...

Journal: :journal of nanostructures 2015
d. moslemi s. mortazavi-derazkola s. masoumeh ghoreishi

in this work we synthesized nano hydroxyapatite (hap)  by sol-gel method, then we functionalized hydroxyapatite nanoparticle by use of  3-aminopropyl trimethoxysilane (aptms) , to improve the loading and control release of sulfasalazine drug bonded to aptms. the drug release patterns from sulfasalazine loaded hap nanoparticles at ph value 8 for 6h, sulfasalazine loaded functionalized hap nanopa...

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