BACKGROUND Gastric cancer is one of the most common cancers in the world. MAC30/Transmembrane protein 97 (TMEM97) is aberrantly up-regulated in many human carcinoma cells. However, the function of MAC30 in gastric carcinoma cells is not studied. MATERIAL AND METHODS To investigate the function of MAC30 in gastric carcinoma, we used RNA silencing technology to knock down the expression of MAC3...

BACKGROUND The caspase-associated recruitment domain-containing protein (CARP) is expressed in almost all tissues. Recently, the tumor-suppressive function of CARP was discovered and attracted increasing attention. This study aimed to investigate the role of CARP in the carcinogenesis of human gastric carcinoma. METHODOLOGY/PRINCIPAL FINDINGS Compared with normal gastric tissue, the downregul...

Gastric carcinoma with lymphoid stroma is a rare and well known entity. Histologically tumour is extremely cellular infiltrated by fairly large number of lymphocytes. The infiltrate can be so dense that a mistaken diagnosis of lymphoma may be made on endoscopic biopsy or even in resection specimen. The entity is known by various names, which include medullary carcinoma with lymphocytic infiltra...

thelioma-like gastric carcinoma that presented as a flat depressed lesion and was treated by complete en-bloc resection using endoscopic submucosal dissection (ESD). A 73-year-old manwas referred to the department of internal medicine because of an incidental finding suspicious of early gastric cancer. The patient’s medical history and laboratory test results were unremarkable. Gastroscopy reve...

Gastric tumors share many characteristics, making a definitive diagnosis challenging. Gastric adenocarcinomas represent 90% of malignant stomach tumors, meanwhile the frequency of gastric lymphoma range between 1-5% of all gastric cancers. Gastric carcinoma bears resemblance with particular forms of non-Hodgkin's lymphoma of the stomach, not only in morphological presentation, but also in clini...

The most common type of gastric carcinoma, namely the intestinal type, has been proposed to result from a precancerous process in which chronic gastritis, atrophy, intestinal metaplasia and dysplasia develop in a sequential manner. Helicobacter pylori is considered as the main cause of chronic atrophic gastritis and thus may play a role in the gastric carcinogenesis process. The present study w...

We conducted a clinicopathological study of cases of gastric carcinoma with pyloric stenosis and examined treatment outcomes and the prognosis of cases of stage IV gastric carcinoma with pyloric stenosis and the validity of gastrectomy as palliative surgery in these cases. The outcomes of 49 surgeries for gastric carcinoma with pyloric stenosis were compared with those of 671 surgeries for gast...

UNLABELLED Gastric carcinoma occurs in response to chronic inflammation of gastric mucosa infected with Helicobacter pylori. It is not known how cytokines affect the growth and progression of gastric carcinoma. MATERIALS AND METHODS We measured tissue concentrations of the proinflammatory cytokines interleukin (IL)-1beta and IL-6 in gastric carcinoma and investigated the correlation between t...

there are many techniques for reconstruction after total pharyngolaryngoesophagectomy. the use of a transposed stomach to restore gastrointestinal continuity, and this combined cervical and abdominal approach for pharyngolaryngoesophagectomy and gastric pull up has become one of the most popular. this retrospective study is a review of 50 consecutive iranian patients who underwent pharyngolaryn...

BACKGROUND Numerous components of fruit and vegetables are considered to decrease the risk of gastric carcinoma. In the current prospective study, the authors examined the association between the intake of vitamins, carotenoids, and dietary fiber and vitamin supplement use and the incidence rate of gastric carcinoma. METHODS The Netherlands Cohort Study began in 1986 with 120,852 men and wome...