abstract objective the last two decades have seen major advancements in our understanding of some of the most common neurodevelopmental disorders in the field of child neurology. however, in the majority of individual patients, it is still not possible to arrive at a molecular diagnosis, due in part to lack of knowledge of molecular causes of these tremendously complex conditions. common geneti...

In genetics, linkage disequilibrium (LD) is a phenomenon arising from the co-inheritance of alleles at nearby loci on the same chromosome, i.e., the alleles at multiple tightly linked genetic loci pass nonrandomly from generation to generation in a natural population. Capitalizing on this phenomenon, a group of mapping methods, called LD mapping, have been developed recently for genetic associa...

Carlborg, Ö. 2002. New Methods for Mapping Quantitative Trait Loci. Doctoral dissertation. ISSN 1401-6257, ISBN 91-576-6362-9 This thesis presents and discusses the use of various genetic models, high performance computing, global optimization algorithms and statistical methods for mapping Quantitative Trait Loci (QTL). The aim of the work has been to develop statistically powerful and computat...

Functional mapping has emerged as a powerful tool for mapping quantitative trait loci (QTL) that control developmental patterns of complex dynamic traits. Original functional mapping has been constructed within the context of simple interval mapping, without consideration of separate multiple linked QTL for a dynamic trait. In this article, we present a statistical framework for mapping QTL tha...

Expressed sequence tags simple sequence repeats (EST-SSRs) are important sources for investigation of genetic diversity and molecular marker development. Similar to genomic SSRs, the EST-SSRs are useful markers for many applications in genetics and plant breeding such as genetic diversity analysis, molecular mapping and cross-transferability across related species and genera. In spite of low po...

This paper addresses energy-aware application mapping for large-scale Network-on-chip (NoC). The increasing number of intellectual property (IP) cores in multi-processor system-on-chips (MPSoCs) makes NoC application mapping more challenging to find optimum core-to-topology mapping. This paper proposes an application mapping technique that incorporates domain knowledge into genetic algorithm (G...