The study was conducted to measure the effect of baseline serum calcium levels on the stage of nephrotoxicity caused by Gentamicin therapy for neonates' patients in teaching hospital, highlight the mechanism(s) behind this type of toxicity and setting a therapy regimen to minimize or delay such toxicity caused by Gentamicin. Retrospectively, the renal function indicators values such as BUN, Src...

Background: Nephrotoxicity refers to the toxigenic impact of compounds and medications on kidney function. There are a variety drug formulations, some medicines that may affect renal function in multiple ways via nephrotoxins production. Nephrotoxins substances harmful kidneys. Purpose: This investigation examines renoprotective effect gymnemic acid (GA) Wistar rats gentamicin-induced nephrotox...

BACKGROUND: Nephrotoxicity of Gentamicin (GM), an important aminoglycoside, is still a serious issue in clinical use. Therefore, natural products are currently being used as alternate source medicinal substances by researchers all over the world for new medication molecules. Eruca sativa shows several health benefits that appear to be associated with content flavonoids. objective present study ...

AIM Impact of gender on aminoglycoside induced nephrotoxicity is still controversial and inconclusive. The objective of this study was to investigate the nephrotoxic potential of amikacin (AK) and gentamicin (GM) in male and female hospitalized patients. METHODOLOGY A one-year, non-interventional prospective study of patients administered either GM or AK. The study was carried out at the inte...

Studies were undertaken to characterize the mechanism of aminoglycoside-induced nephrotoxicity. Early time points in gentamicin treatment (1 to 3 d) were used to investigate the development of toxic events without the complication of gross morphologic cellular alterations. Enzyme activities of cortical homogenates and brush border membrane (BBM) preparations documented little effect on specific...

Background and Methodology: Gentamicin is a broad-spectrum antibiotic with restricted application in man and stock due to its side effects such as Nephrotoxicity and autotoxicity. Cinnamon bark has antioxidant properties. This is the first study on the protective effects of the hydroalcoholic extract of cinnamon on gentamicin-induced nephrotoxicity.Methods and Materials: Thirty-six mature femal...

Nephropathies and especially nephrotoxicity have become one of the serious causes life-threatening conditions because intensive exposure to xenobiotic whether by environmental pollution or drug abuse. The present study was undertaken assess protective effects Cinnamomum zeylanicum stem bark aqueous extract (AECZ) on gentamicin-induced nephrotoxicity. AECZ prepared maceration in water tested ora...

Gentamicin and vitamin C have been proposed as nephrotoxic and antioxidant, respectively. This study involved biochemical and histopathologic investigation showing protection and treatment of gentamicin-induced nephrotoxicity in rabbits using vitamin C for 26 days hypothesizing that whether vitamin C would inhibit or decrease the raised serum urea and creatinine levels. This study was conducted...

Previous findings have demonstrated that β-sitosterol (BSS), an active component of Cistanches Herba, protected against oxidant injury in H9c2 cardiomyocytes and in rat hearts by enhancing mitochondrial glutathione redox cycling, possibly through the intermediacy of mitochondrial reactive oxygen species production. We therefore hypothesized that BSS pretreatment can also confer tissue protectio...

The possibility that the nephrotoxicity of gentamicin may be potentiated by the concomitant administration of cephalothin was examined in a rat model. Cephalothin given once daily in dosages up to 800 mg/kg per day for 10 days produced no renal damage. Gentamicin, at 6 to 50 mg/kg per day, caused pathological changes which were dosage related and affected primarily the proximal tubular cells. A...