Hyperlipidemia associated with an isolated deficiency of growth hormone was investigated in 10 subjects with hypercholesterolemia consistently present over a 10-yr period. 8 of these 10 had serum triglyceride concentrations greater than 185 mg/dl. 13 growth hormone-deficient patients with normal serum lipids, 28 age-matched controls, and 6 families possessing both growth hormone-deficient and h...

Introduction: Acute Lymphoblastic Leukemia (ALL) and Non Hodgkin’s Lymphoma(NHL) are the most common cancers in childhood and  adolescence. Most children with ALL and NHL have long term survival (>80%). Endocrinopathy is a common complication in pediatric cancers following the treatment (20-50% prevalence), in addition, cytotoxic chemotherapy and radiotherapy can influence side effect on growt...

In four acromegalic patients, estrogen therapy did not significantly alter the mean values of basal radioimmunoassayable plasma growth hormone. In two patients, estrogen therapy did not qualitatively alter the lack of reduction of plasma growth hormone levels after oral administration of glucose, nor did it reduce in these patients the response of plasma growth hormone to insulin-induced hypogl...


 Early initiation of growth hormone therapy is recommended in children with Turner syndrome if the child already has failure or a high chance short stature (1 guideline).
 Growth treatment can be started at 45 mcg/kg/day to 50 Monitor by regular height measurements and assessment levels insulin-like factor-I Continue until desired achieved when no more potential remains

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Conclusions drawn from the pancreatic (or islet) clamp technique (suppression of endogenous insulin, glucagon, and growth hormone secretion with somatostatin and replacement of basal hormone levels by intravenous infusion) are critically dependent on the biological appropriateness of the selected doses of the replaced hormones. To assess the appropriateness of representative doses we infused sa...

BACKGROUND Systemic lupus erythematosus is an age- and gender-associated autoimmune disorder. Previous studies suggested that defects in the hypothalamic/pituitary axis contributed to systemic lupus erythematosus disease progression which could also involve growth hormone, insulin-like growth factor-1 and somatostatin function. This study was designed to compare basal serum growth hormone, insu...

Several studies have revealed that the majority of dwarfs with isolated growth hormone deficiency show low insulin response to glycemic and arginine stimulation tests and some have a tendency to develop glucose intolerance (Frohmann, MacGillivray and Aceto 1967, Merimee, Rabinovitz, Rimoin and McKusick 1968, Gold, Spector, Samaan and Pearson 1968). On the basis of sensitivity to exogenous insul...