نتایج جستجو برای: gstm1
تعداد نتایج: 1660 فیلتر نتایج به سال:
Abstract Background &Aims: Male factors account for 20%-50% of cases of infertility and male infertility due to severe oligozoospermia and azoospermia has been associated with a number of genetic risk factors. Severe oligozoospermia was defined as a concentration of less than 5×106 sperm/ml. The aim of this study was to examine whether an association exists between glutathione S-tr...
Background: Pi-GST and Mu-GST are subclasses of glutathione S-transferase that present on human sperm surface and play an important role against oxidative stress. Therefore, any defects in the enzyme activity may be associated with male infertility.In this study the polymorphisms of GSTM1 and GSTP1 in association with enzyme activity and sperm parameters were studied. Methods: This case-contro...
Background and purpose: Glutathion S-transferase (GSTs) are a family of detoxification phase II enzymes that catalyze the conjugation of carcinogenic and cytotoxic componds with glutathion. GSTs are polymorphic and deletion of GSTM1 and GSTT1 polymorphism is caused by lack of enzyme production that lead to loss of antioxidant activity. In this study, we examined the frequency of GSTM1 and G...
BACKGROUND & OBJECTIVE Endometriosis is one of the most commonly encountered benign problems in gynaecology. It is frequently associated with chronic pelvic pain, dysmenorrhoea, menorrhagia and dyspareunia, which lead to infertility. To determine the possible association between polychlorinated biphenyls (PCBs) and GSTM1 null (*0/*0) mutation and their possible impact in the pathogenesis of end...
AIM We conducted a meta-analysis to analyze the influence of GSTM1 and GSTT1 gene polymorphisms on cervical cancer risk, and explore gene-environment interactions. METHODS Identification of relevant studies was carried out through a search of Medline and the EMbase up to Oct. 2011. All case-control studies that investigated the association between GSTM1 and GSTT1 gene polymorphisms and risk o...
BACKGROUND Glutathione S-transferases (GSTs) are a family of multifunctional enzymes that are involved in the metabolism of many xenobiotics, including a wide range of environmental carcinogens. While the null genotypes in GSTM1 and GSTT1 have been implicated in tumorigenesis, it remains inconsistent and inconclusive. Herein, we aimed to assess the possible associations of the GSTM1 and GSTT1 n...
PURPOSE To investigate possible associations between the gene number and allelic forms of glutathione S-transferase M1 (GSTM1) and the occurrence of nucleic and cortical age-related cataracts. METHODS Patients with cortical cataract, nuclear cataract, mixed and cortical cataract, and no cataract were sytematically selected from subjects evaluated in the Italian-American Study of the Natural H...
This study investigated associations between occupational pesticide exposure and renal cell carcinoma (RCC) risk. To follow-up on a previous report by Buzio et al., we also considered whether this association could be modified by glutathione S-transferase M1 and T1 (GSTM1 and GSTT1) genotypes. About 1097 RCC cases and 1476 controls from Central and Eastern Europe were interviewed to collect dat...
Introduction: Glutathione S-tarnsferases (GST) gene family is one of the enzymes which is responsible for detoxifying mutagens and Carcinogens chemicals. People with null genotype of GSTM1 and GSTT1 genes are at higher risk of developing cancer, especially those who are related to smoking. The goal of this study was investigating the rate of glutathione S-transferase T1 and M1 genes deletion an...
مقدمه: آسیب به dna ، نقش مهمی در بیماریهای مختلف بازی می کند . این آسیب در اثر مواد اکسیدانت و موتاژن ها رخ می دهد . گلوتاتیون- s ترانسفرازها اعضای یک خانواده چند ژنی هستند که به عنوان یک آنتی اکسیدانت مهم در سلولها ایفای نقش می کنند . پلی مورفیسم این آنزیم در بیماریهای مختلف ،مورد بحث و بررسی قرار گرفته است. در این مطالعه ،به بررسی پلی مورفیسم ژنوتیپ های gstm1,t1 در بیماران مبتلا به گلوکومای ا...
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