Differences in microscopic structure of the femur between 1-month-old transgenic rabbits carrying the hFVIII gene and non-transgenic rabbits were investigated. Bone microstructure was evaluated from the point of view of qualitative and quantitative histological characteristics. We identified fibrolamellar bone tissue only in the transgenic animals. Measured values for area, perimeter of the Hav...

Introduction: Bone metastases are established when cancer cells reach the bone marrow through blood vessels in Haversian canals, extravasate, multiply, and eventually neovascularize. Metastatic bone lesions can be classified as osteolytic, osteoblastic and mixed. In osteolytic lesions, which are the most common, bone destruction outstrips the laying down of new bone. Osteoblastic lesions result...

In densely populated countries like Italy, cremation is promoted for the final disposition of dead. However, many families still choose inhumation or entombment. ordinary (traditional) tombs, bodies skeletonize slowly and partially, often need a second disposal after exhumation. The aim this study was to experimentally test functionality new type tomb, defined as “aerated”. Aerated tombs featur...

During bone remodeling, osteoblasts are known to deposit unmineralized collagenous tissue (osteoid), which mineralizes after some time lag. Some of the differentiate into osteocytes, forming a cell network within lacunocanalicular (LCN) bone. To get more insight potential role osteocytes in mineralization process osteoid, sites formation three-dimensionally imaged nine human osteons using focus...

As it is well known, bone tissue is characterized by a calcified extracellular matrix which makes this tissue suitable to support the body and protect the inner organs. Lamellar bone tissue is organized in lamellae, 3-7 microm in thickness, and arranged concentrically around vascular channels: the basic structure in this type of organization is called Haversian system or osteon and the diameter...