نتایج جستجو برای: hdac11
تعداد نتایج: 106 فیلتر نتایج به سال:
BACKGROUND Balkan endemic nephropathy (BEN) represents a chronic progressive interstitial nephritis in striking correlation with uroepithelial tumours of the upper urinary tract. The disease has endemic distribution in the Danube river regions in several Balkan countries.DNA methylation is a primary epigenetic modification that is involved in major processes such as cancer, genomic imprinting, ...
During normal development and throughout life, epigenetic changes arise in response to an individuals’ behavior environment. Histone deacetylases (HDACs) are chromatin-modifying enzymes that remove acetyl groups from histones, inducing conformational DNA changes, so regulating gene expression. To date, four classes of HDACs have been identified: class I (HDACs-1, -2, -3 & -8); II (HDACs-4, -5, ...
Histone deacetylases (HDACs) modify core histones and participate in large regulatory complexes that both suppress and enhance transcription. Recent studies indicate that some HDACs can act on non-histone proteins as well. Interest in these enzymes is growing because HDAC inhibitors appear to be promising therapeutic agents against cancer and a variety of other diseases. Thus far, 11 members of...
PURPOSE Medulloblastomas are the most common malignant brain tumors in childhood. Survivors suffer from high morbidity because of therapy-related side effects. Thus, therapies targeting tumors in a specific manner with small molecules such as histone deacetylase (HDAC) inhibitors are urgently warranted. This study investigated the expression levels of individual human HDAC family members in pri...
Monoaminergic and Neuropeptidergic Neurons Have Distinct Expression Profiles of Histone Deacetylases
Monoaminergic and neuropeptidergic neurons regulate a wide variety of behaviors, such as feeding, sleep/wakefulness behavior, stress response, addiction, and social behavior. These neurons form neural circuits to integrate different modalities of behavioral and environmental factors, such as stress, maternal care, and feeding conditions. One possible mechanism for integrating environmental fact...
A number of cellular processes, as cell proliferation, apoptosis and cytoskeleton assembly [1], are regulated by enzymes belonging to the family of histone deacetylases (HDACs). Extended or local changes in chromatin structure are driven by an interplay between histone acetyltransferases (HATs) and HDACs, and both of enzymes are involved in post-translational modifications of histones involving...
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