The objective of this study was to characterize the effects of acute anoxia on contractile and electrical activity in the heart of an anoxia-tolerant fish species, the crucian carp ( Carassius carassius L.). Responses of atrial and ventricular tissue or isolated cells to NaCN, adenosine, and carbachol were determined to examine the effects of anoxia on cardiac performance and to clarify the pos...

The heart is a major target organ for thyroid hormone action. Severe overt hypothyroidism can result in diastolic hypertension, lowered cardiac output, impaired left ventricular contractility and diastolic relaxation, pericardial effusion and bradycardia. However, the function of the atrial pacemaker is usually normal and the degree by which the heart rate slows down is often modest. Here we re...

A clinical case of successful surgical treatment in a patient with severe New York Heart Association (NYHA) functional class IIIIV heart failure, critical aortic stenosis, and extremely low left ventricular (LV) ejection fraction (EF) (16%) is presented. Aortic valve leaflet replacement was performed according to the Ozaki technique. The postoperative course uneventful discharged from hospital ...

The case is reported of an athlete who, during an exercise test, had a complete atrioventricular block without symptoms of cardiac output failure. Heart rate, stroke index, cardiac index, and myocardial contractility were monitored during the episode by an impedance cardiograph. The most important findings of this report are the continuous increase in stroke index, which compensated for the lac...

BACKGROUND Cardiac contractility modulation signals are associated with acutely improved hemodynamics, but chronic clinical impact is not defined. OBJECTIVES The purpose of this randomized, double-blind, pilot study was to determine the feasibility of safely and effectively delivering cardiac contractility modulation signals in patients with heart failure. METHODS Forty-nine subjects with e...

Although metabolic acidemia reduces the contractility of cardiac muscle in isolated preparations, it does not do so to the same extent in intact animals or those with a functioning sympathoadrenal system. The present study was designed to determine if the resistance of the heart to acidemia is the consequence of concurrent adrenergic influences on the myocardium. The function of the cat's left ...

WALLACE, ANDREW G., N. SHELDON SKINNER, JR., AND JERE H. MITCHELL. Hemodynamic determinants of the maximal rate of rise of left ventricular pressure. Am, J. Physiol. 205 (I) : 30-36. 1963. -The maximal rate of left ventricular pressure development (max. dp/dt) was measured in an arenexic preparation which permitted independent control of stroke volume, heart rate, and aortic pressure. Max. dp/d...

OBJECTIVE To determine if bradycardia during hyperbaric exposure is accompanied by a negative influence on myocardial contractility. METHODS Accelerometer-based registration of myocardial compression waves with Seismocardiography (SCG) for noninvasive contractility monitoring. Comparative pulmonary artery (PA) catheter study (9 ICU-patients, mean = 67ys) with ejection-fraction (EF) equivalent...