We have developed defined genetic lines of the hydroid Hydractinia symbiolongicarpus and confirmed earlier results showing that allorecognition is controlled by a single chromosomal region within these lines. In a large backcross population, we detected recombinants that display a fusibility phenotype distinct from typical fusion and rejection. We show that this transitory fusion phenotype segr...

We have studied a family in which the proband had systemic lupus erythematosus and selective incomplete deficiency of the fourth component of complement (C4) (2-5% of the normal level). An additional six healthy family members also had low C4 levels (2.4-24.1% of normal) but no evidence of lupus. This form of inherited C4 deficiency differs from that in previously reported families in that inhe...

A. Chandraker et al. (eds.), Core Concepts in Renal Transplantation, DOI 10.1007/978-1-4614-0008-0_2, © Springer Science+Business Media, LLC 2012 Abstract Predicting humoral alloimmune potential in transplant recipients is the objective of histocompatibility testing and depends upon accurate donor typing and sensitive and specifi c testing for antibodies to human leukocyte antigen. This review ...

T-cells are part of our adaptive immune system and responsible for recognition antigens in bodies. T-cell activation is triggered upon binding receptor (TCR) to major histocompatibility complex loaded with antigenic peptide (pMHC) which presented on the surface antigen presenting cells (APC). According kinetic segregation model activation, topography plays a large role process. In this study we...