the object of this cross sectional study was to determine the hcv subtype 3a envelope protein binding affinity with human leukocyte antigen. envelope 1 (e1) protein is one of the structural proteins responsible for entering the cells through the receptors. the binding affinity of e1 protein epitopes to the selected human leukocyte antigen (hla) class i alleles was investigated using the compute...

objective(s): htlvi-1 is the first human retrovirus with limited endemic regions in the world. the epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in htlv-i-associated diseases.  among the genes are involved in htlv-i infection, the role of human leukocytes antigen (hla) have been studied in different population. in the pre...

OBJECTIVES The population in Iran is a genetic admixture of the ancestral Aryan and other populations neighboring Iran. Different ethnic groups in Iran show wide regional distributions for many human leukocyte antigen (HLA) alleles. Therefore, it is necessary and sensible to study the differences in HLA allele distribution in different area. We studied the HLA class I and II allele frequencies ...

Imputation of human leukocyte antigen (HLA) alleles from SNP-level data is attractive due to importance of HLA alleles in human disease, widespread availability of genome-wide association study (GWAS) data, and expertise required for HLA sequencing. However, comprehensive evaluations of HLA imputations programs are limited. We compared HLA imputation results of HIBAG, SNP2HLA, and HLA*IMP:02 to...

OBJECTIVE To identify T-cell epitopes of Ag85B by analysis of its sequence for prediction to bind HLA-DR alleles and evaluate the predicted peptides for recognition by T cells in antigen-induced proliferation assays. MATERIALS/SUBJECTS AND METHODS The complete sequence of Ag85B was analyzed for HLA-DR binding prediction to 51 HLA-DR alleles by using a virtual matrix-based prediction program (...

HLA class I glycoproteins contain the functional sites that bind peptide antigens and engage lymphocyte receptors. Recently, clinical application of sequence-based HLA typing has uncovered an unprecedented number of novel HLA class I alleles. Here we define the nature and extent of the variation in 3,489 HLA-A, 4,356 HLA-B and 3,111 HLA-C alleles. This analysis required development of suites of...

OBJECTIVE We report here the human leukocyte antigen (HLA) allelic variety and haplotype composition in a cohort of the Taiwanese Chinese population and their patterns of linkage disequilibria on HLA-B: HLA-C alleles and HLA-DRB1: HLA-DQB1 alleles at a high-resolution level. MATERIALS AND METHODS Peripheral whole blood from 11,423 Taiwanese Chinese unrelated individuals was collected in acid ...

background: hla-g gene contains 15 alleles including a null allele, hla-g*0105n. previous studies have shown that hla-g*0105n does not encode the complete hla-g1 or hla-g5 isoforms but encodes a functional hla-g protein with the ability to in-hibit nk cell cytolysis. thus, although the biological functions of hla-g1 and hla-g5 proteins are abrogated, other isoforms such as hla-g2 can replace th...

BACKGROUND Human leukocyte antigen (HLA) alleles code for proteins that are involved in the recognition of foreign antigens and activation of the immune system. The frequency of HLA alleles varies across different populations. OBJECTIVE To describe the frequency of HLA alleles in a population of Inuit women of Nunavik, Quebec, Canada. DESIGN A cohort of women was recruited from 4 different ...