BACKGROUND Hydroxyurea (HU) is the only disease-modifying medication for patients with sickle cell disease (SCD). HU can reduce SCD-related complications but only 35% to 50% of pediatric patients adhere to HU at the rates achieved in clinical trials and this limits its clinical effectiveness. Mobile Directly Observed Therapy (Mobile DOT) is a pilot-tested, electronic, multidimensional, HU adher...

The present study evaluated the antihyperglycaemic effect and mechanism of action of fractions of the aqueous seed extract of Hunteria umbellata (K. Schum.) Hallier f. (HU) in normal and alloxan-induced hyperglycaemic rats. HU was partitioned in chloroform, acetyl acetate and butan-1-ol to give chloroform fraction (HU c), ethyl acetate fraction (HU e), butanol fraction (HU b) and the "residue" ...

In this paper the solution of two-stage guillotine cutting stock problems is considered. Especially such problems are under investigation where the sizes of the order demands diier in a large range. We propose a new approach dealing with such situations and compare it with the classical Gilmore/Gomory approach. We report results of extensive numerical experiments which show the advantages of th...

OBJECTIVE To develop a new method to determine the presence of intracochlear ossification and/or fibrosis in cochlear implantation candidates with bilateral profound deafness following meningitis. STUDY DESIGN Diagnostic test assessment. SETTING A university hospital. SUBJECTS AND METHODS This study involved 15 ears from 13 patients with profound deafness following meningitis who underwen...

In cite{Kats84}, Katsaras introduced a method for constructing a Hu-tton $[0,1]$-quasi-uniformity from a crisp uniformity. In this paper we present other different methods for making this based mainly in the concept of a fuzzy uniform structure. Furthermore, we prove that some of these methods preserve the completeness property of the quasi-uniformity.  Moreover, we also show that Katsaras' con...

OBJECTIVES To follow up the level of anti-Hu antibody titres during chemotherapy and to compare the pattern of metastases and other neurological complications before and after chemotherapy in patients with small cell lung cancer (SCLC) with and without low titre anti-Hu antibodies. Seventeen per cent of patients with SCLC without paraneoplastic syndromes have a low titre of anti-Hu antibodies i...

BACKGROUND Hydroxyurea (HU) is an immunomodulatory agent that has been documented to enhance the antiretroviral activity of nucleoside reverse transcriptase inhibitors, such as abacavir (ABC) and didanosine (ddI), and would be expected to improve virologic efficacy. METHODS A 48-week, phase IV, multicenter, open-label, proof-of-concept clinical trial was conducted to evaluate second-line, pro...

OBJECTIVE The purpose of this study was to investigate the relationship between visual score of emphysema and homology-based emphysema quantification (HEQ) and evaluate whether visual score was accurately predicted by machine learning and HEQ. MATERIALS AND METHODS A total of 115 anonymized computed tomography images from 39 patients were obtained from a public database. Emphysema quantificat...

Figure 1. Professor Da-Yi Hu, MD, FACC Professor Da-Yi Hu (Figure 1) was born in Henan province of central China, in 1946. He graduated from the Beijing Medical School (now Peking University Health Science Center) in 1970 and furthered his education both at SUNY-Oswego and University of Illinois from 1985 to 1987. Professor Hu has been a pioneer in the field of radio-frequency ablation technolo...