OBJECTIVE Severe hyponatremia due to hypopituitarism and adrenal insufficiency can be life-threatening, and treatment with glucocorticoids is very effective once the diagnosis of the underlying disorder has been made. In our experience, the diagnosis of hypopituitarism in hyponatremic patients is often overlooked. METHODS In a retrospective study we screened the files of 185 patients with sev...

Abstract The prevalence of pituitary disease is increasing mainly because advances in modern imaging techniques and an increased awareness among the medical community. Pituitary tumours constitute 10–15% all diagnosed intracranial neoplasms, their clinical manifestations result from local mass effects (mostly neurological, visual, hypopituitarism) and/or hypersecretion. adenomas are mo...

The diagnosis of hypopituitarism in childhood, particularly in the idiopathic type, has been a matter of great difficulty. Growth retardation is the constant presenting sign, and since this is a common occurrence in childhood, differential diagnosis has required an assessment of the clinical story and the results of investigations which too often have not yielded a precise answer. Most of the c...

Carotid-cavernous fistulas (CCFs) are rare, pathologic communications of the carotid artery and the venous plexus of the cavernous sinus. They can develop spontaneously in certain at risk individuals or following traumatic head injury. Typical clinical manifestations include headache, proptosis, orbital pain, and diplopia. We report a case of bilateral carotid-cavernous fistulas associated with...

Hypopituitarism in leukemia is very rare. In addition, central nervous system (cns) relapse and leukemic retinopathy in childhood acute lymphoblastic leukemia (all) have declined with the use of modern systemic chemotherapy that includes cns prophylaxis. Here, we report the case of a 4-year-old girl who received chemotherapy and intrathecal therapy without cns radiation after a diagnosis of B-p...

It has been emphasized by Sheehan (1948) that the criterion for the diagnosis of hypopituitarism is destruction of the anterior pituitary, the most frequent cause being post-partum necrosis. Hypopituitarism in the male is relatively uncommon. Escamilla and Lisser (1942), in a survey of 101 " typical clinical cases with pathological verification," found only 35 in the male. The following case, w...